ethyl 2-(1-benzyl-6',7'-dihyrospiro[piperidine-4,4'-thieno[3,2-c]pyran]-6'-yl)acetate

Base Information

Chemical Name:ethyl 2-(1-benzyl-6',7'-dihyrospiro[piperidine-4,4'-thieno[3,2-c]pyran]-6'-yl)acetate
CAS No.:1093379-06-6
Molecular Formula:C₂₂H₂₇NO₃S
Molecular Weight:385.527
Hs Code.:

Synonyms:ethyl 2-(1-benzyl-6',7'-dihyrospiro[piperidine-4,4'-thieno[3,2-c]pyran]-6'-yl)acetate

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Chemical Property of ethyl 2-(1-benzyl-6',7'-dihyrospiro[piperidine-4,4'-thieno[3,2-c]pyran]-6'-yl)acetate

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Technology Process of ethyl 2-(1-benzyl-6',7'-dihyrospiro[piperidine-4,4'-thieno[3,2-c]pyran]-6'-yl)acetate

There total 5 articles about ethyl 2-(1-benzyl-6',7'-dihyrospiro[piperidine-4,4'-thieno[3,2-c]pyran]-6'-yl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

: 1093378-99-4
1-benzyl-6',7'-dihydrospiro[piperidine-4,4'-thieno[3,2-c]pyran]-6'-ol

: 1099-45-2
ethyl (triphenylphosphoranylidene)acetate

: 1093379-06-6
ethyl 2-(1-benzyl-6',7'-dihyrospiro[piperidine-4,4'-thieno[3,2-c]pyran]-6'-yl)acetate

Guidance literature:: With potassium tert-butylate; In tetrahydrofuran; for 10.5h; Reflux;
DOI:10.1021/jm300302p

Reference yield:

: (E/Z)-3-bromo-2-(2-methoxyvinyl)thiophene

: 1093379-06-6
ethyl 2-(1-benzyl-6',7'-dihyrospiro[piperidine-4,4'-thieno[3,2-c]pyran]-6'-yl)acetate

Guidance literature:: Multi-step reaction with 5 steps

1.1: toluene-4-sulfonic acid / methanol / 24 h / Heating / reflux

2.1: n-butyllithium / tetrahydrofuran; hexane / 0.28 - 0.3 h / -84 °C

2.2: 3 h / -84 - 20 °C

3.1: toluene-4-sulfonic acid; trimethyl orthoformate / methanol / 24 h / 20 °C

4.1: hydrogenchloride / water; acetonitrile / 1 h / Heating / reflux

4.2: pH > 9

5.1: potassium tert-butylate / tetrahydrofuran / 10.5 h / Heating / reflux

With hydrogenchloride; n-butyllithium; potassium tert-butylate; toluene-4-sulfonic acid; trimethyl orthoformate; toluene-4-sulfonic acid; In tetrahydrofuran; methanol; hexane; water; acetonitrile;

Reference yield:

: 1070709-12-4
1-benzyl-6'-methoxy-6',7'-dihydrospiro[piperidine-4,4'-thieno[3,2-c]pyran]

: 1093379-06-6
ethyl 2-(1-benzyl-6',7'-dihyrospiro[piperidine-4,4'-thieno[3,2-c]pyran]-6'-yl)acetate

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogenchloride / water; acetonitrile / 1 h / Reflux

2: potassium tert-butylate / tetrahydrofuran / 10.5 h / Reflux

With hydrogenchloride; potassium tert-butylate; In tetrahydrofuran; water; acetonitrile;
DOI:10.1021/jm300302p