(5S,8S,11R,14R)-tert-butyl 5-(2-tert-butoxy-2-oxoethyl)-8-(3-tert-butoxy-3-oxopropyl)-14-(4-(hydroxymethyl)phenylcarbamoyl)-11-isopropyl-3,6,9,12-tetraoxo-1-phenyl-2-oxa-4,7,10,13-tetraazahexadecan-16-oate

Base Information

Chemical Name:(5S,8S,11R,14R)-tert-butyl 5-(2-tert-butoxy-2-oxoethyl)-8-(3-tert-butoxy-3-oxopropyl)-14-(4-(hydroxymethyl)phenylcarbamoyl)-11-isopropyl-3,6,9,12-tetraoxo-1-phenyl-2-oxa-4,7,10,13-tetraazahexadecan-16-oate
CAS No.:1374040-16-0
Molecular Formula:C₄₅H₆₅N₅O₁₃
Molecular Weight:884.037
Hs Code.:

(5S,8S,11R,14R)-tert-butyl 5-(2-tert-butoxy-2-oxoethyl)-8-(3-tert-butoxy-3-oxopropyl)-14-(4-(hydroxymethyl)phenylcarbamoyl)-11-isopropyl-3,6,9,12-tetraoxo-1-phenyl-2-oxa-4,7,10,13-tetraazahexadecan-16-oate

Synonyms:(5S,8S,11R,14R)-tert-butyl 5-(2-tert-butoxy-2-oxoethyl)-8-(3-tert-butoxy-3-oxopropyl)-14-(4-(hydroxymethyl)phenylcarbamoyl)-11-isopropyl-3,6,9,12-tetraoxo-1-phenyl-2-oxa-4,7,10,13-tetraazahexadecan-16-oate

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Chemical Property of (5S,8S,11R,14R)-tert-butyl 5-(2-tert-butoxy-2-oxoethyl)-8-(3-tert-butoxy-3-oxopropyl)-14-(4-(hydroxymethyl)phenylcarbamoyl)-11-isopropyl-3,6,9,12-tetraoxo-1-phenyl-2-oxa-4,7,10,13-tetraazahexadecan-16-oate

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Technology Process of (5S,8S,11R,14R)-tert-butyl 5-(2-tert-butoxy-2-oxoethyl)-8-(3-tert-butoxy-3-oxopropyl)-14-(4-(hydroxymethyl)phenylcarbamoyl)-11-isopropyl-3,6,9,12-tetraoxo-1-phenyl-2-oxa-4,7,10,13-tetraazahexadecan-16-oate

There total 2 articles about (5S,8S,11R,14R)-tert-butyl 5-(2-tert-butoxy-2-oxoethyl)-8-(3-tert-butoxy-3-oxopropyl)-14-(4-(hydroxymethyl)phenylcarbamoyl)-11-isopropyl-3,6,9,12-tetraoxo-1-phenyl-2-oxa-4,7,10,13-tetraazahexadecan-16-oate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 1374040-14-8
(R)-tert-butyl 3-amino-4-(4-(hydroxymethyl)phenylamino)-4-oxobutanoate

: 1374040-15-9
z-DEVD-CO₂H

: 1374040-16-0
(5S,8S,11R,14R)-tert-butyl 5-(2-tert-butoxy-2-oxoethyl)-8-(3-tert-butoxy-3-oxopropyl)-14-(4-(hydroxymethyl)phenylcarbamoyl)-11-isopropyl-3,6,9,12-tetraoxo-1-phenyl-2-oxa-4,7,10,13-tetraazahexadecan-16-oate

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; for 18h;

Reference yield:

: 1374040-13-7
tert-butyl (R)-3-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-4-((4-(hydroxymethyl)phenyl)amino)-4-oxobutanoate

: 1374040-16-0
(5S,8S,11R,14R)-tert-butyl 5-(2-tert-butoxy-2-oxoethyl)-8-(3-tert-butoxy-3-oxopropyl)-14-(4-(hydroxymethyl)phenylcarbamoyl)-11-isopropyl-3,6,9,12-tetraoxo-1-phenyl-2-oxa-4,7,10,13-tetraazahexadecan-16-oate

Guidance literature:: Multi-step reaction with 2 steps

1: piperidine / N,N-dimethyl-formamide / 4 h

2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 18 h

With piperidine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide;