6'-[tert-butoxycarbonyl-(3-chloro-phenyl)-amino]-[2,2']bipyrazinyl-6-carboxylic acid

Base Information

Chemical Name:6'-[tert-butoxycarbonyl-(3-chloro-phenyl)-amino]-[2,2']bipyrazinyl-6-carboxylic acid
CAS No.:405939-76-6
Molecular Formula:C₂₀H₁₈ClN₅O₄
Molecular Weight:427.847
Hs Code.:

6'-[<i>tert</i>-butoxycarbonyl-(3-chloro-phenyl)-amino]-[2,2']bipyrazinyl-6-carboxylic acid

Synonyms:6'-[tert-butoxycarbonyl-(3-chloro-phenyl)-amino]-[2,2']bipyrazinyl-6-carboxylic acid

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Chemical Property of 6'-[tert-butoxycarbonyl-(3-chloro-phenyl)-amino]-[2,2']bipyrazinyl-6-carboxylic acid

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Technology Process of 6'-[tert-butoxycarbonyl-(3-chloro-phenyl)-amino]-[2,2']bipyrazinyl-6-carboxylic acid

There total 5 articles about 6'-[tert-butoxycarbonyl-(3-chloro-phenyl)-amino]-[2,2']bipyrazinyl-6-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 405939-19-7
6'-[(tert-butoxycarbonyl)(3-chlorophenyl)amino][2,2']bipyrazinyl-6-carboxylic acid methyl ester

: 405939-76-6
6'-[tert-butoxycarbonyl-(3-chloro-phenyl)-amino]-[2,2']bipyrazinyl-6-carboxylic acid

Guidance literature:: With lithium hydroxide; In tetrahydrofuran; at 20 ℃; for 2h;
DOI:10.1021/jm040099a

Reference yield:

: 405940-12-7
(3-chlorophenyl)(6-chloropyrazin-2-yl)carbamic acid tert-butyl ester

: 405939-76-6
6'-[tert-butoxycarbonyl-(3-chloro-phenyl)-amino]-[2,2']bipyrazinyl-6-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 75 percent / Pd(PPh₃)2Cl₂; LiCl / toluene / 6.5 h / 100 °C

2: 96 percent / aq. LiOH / tetrahydrofuran / 2 h / 20 °C

With bis-triphenylphosphine-palladium(II) chloride; lithium hydroxide; lithium chloride; In tetrahydrofuran; toluene; 1: Stille coupling;
DOI:10.1021/jm040099a

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 405939-76-6
6'-[tert-butoxycarbonyl-(3-chloro-phenyl)-amino]-[2,2']bipyrazinyl-6-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 100 percent / DMAP / CH₂Cl₂ / 16 h / 20 °C

2: 75 percent / Pd(PPh₃)2Cl₂; LiCl / toluene / 6.5 h / 100 °C

3: 96 percent / aq. LiOH / tetrahydrofuran / 2 h / 20 °C

With dmap; bis-triphenylphosphine-palladium(II) chloride; lithium hydroxide; lithium chloride; In tetrahydrofuran; dichloromethane; toluene; 2: Stille coupling;
DOI:10.1021/jm040099a