N-(2-amino-2-methylpropyl) (2S,4S,5S)-5-amino-6-cyclohexyl-4-hydroxy-2-isopropylhexanamide

Base Information

Chemical Name:N-(2-amino-2-methylpropyl) (2S,4S,5S)-5-amino-6-cyclohexyl-4-hydroxy-2-isopropylhexanamide
CAS No.:161316-44-5
Molecular Formula:C₁₉H₃₉N₃O₂
Molecular Weight:341.538
Hs Code.:

Synonyms:N-(2-amino-2-methylpropyl) (2S,4S,5S)-5-amino-6-cyclohexyl-4-hydroxy-2-isopropylhexanamide

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Chemical Property of N-(2-amino-2-methylpropyl) (2S,4S,5S)-5-amino-6-cyclohexyl-4-hydroxy-2-isopropylhexanamide

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Technology Process of N-(2-amino-2-methylpropyl) (2S,4S,5S)-5-amino-6-cyclohexyl-4-hydroxy-2-isopropylhexanamide

There total 2 articles about N-(2-amino-2-methylpropyl) (2S,4S,5S)-5-amino-6-cyclohexyl-4-hydroxy-2-isopropylhexanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 142688-88-8
N-(2-amino-2-methylpropyl)-(2S,4S,5S)-5-((tert-butyloxycarbonyl)amino)-6-cyclohexyl-4-hydroxy-2-isopropyl-hexanamide

: 161316-44-5
N-(2-amino-2-methylpropyl) (2S,4S,5S)-5-amino-6-cyclohexyl-4-hydroxy-2-isopropylhexanamide

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 0 ℃; for 4.5h;
DOI:10.1021/jm00045a003

Reference yield:

: 124032-36-6
(3S,5S)-5-[(1S)-1-(t-butoxycarbonyl)amino-2-cyclohexylethyl]-3-isopropyldihydrofuran-2(3H)-one

: 161316-44-5
N-(2-amino-2-methylpropyl) (2S,4S,5S)-5-amino-6-cyclohexyl-4-hydroxy-2-isopropylhexanamide

Guidance literature:: Multi-step reaction with 2 steps

1: 42 percent / glacial acetic acid / 1.) 50 deg C, 48 h, 2.) 55 deg C, 5 d

2: trifluoroacetic acid / CH₂Cl₂ / 4.5 h / 0 °C

With acetic acid; trifluoroacetic acid; In dichloromethane;
DOI:10.1021/jm00045a003

Reference yield:

: 161316-44-5
N-(2-amino-2-methylpropyl) (2S,4S,5S)-5-amino-6-cyclohexyl-4-hydroxy-2-isopropylhexanamide

: (2S,4S,5S)-5-{(S)-2-[(S)-1-Benzyl-2-(4-methoxymethoxy-piperidin-1-yl)-2-oxo-ethylamino]-hexanoylamino}-6-cyclohexyl-4-hydroxy-2-isopropyl-hexanoic acid [2-(2-hydroxy-ethylamino)-2-methyl-propyl]-amide

Guidance literature:: Multi-step reaction with 3 steps

1: HOBt hydrate, 4-methylmorpholine, EDC / dimethylformamide / 1.) -23 deg C, 4 h, 2.) RT, 18 h

2: 29 percent / HOAc, NaOAc, NaBH₃CN / propan-2-ol / pH 6.0; 1.) 0 deg C, 6 h, 2.) RT, 14 h

3: 35 percent / H₂ / 10percent Pd(OH)2/C / ethyl acetate / 168 h / 3040 Torr

With 4-methyl-morpholine; hydrogen; sodium acetate; sodium cyanoborohydride; benzotriazol-1-ol; acetic acid; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; palladium dihydroxide; In ethyl acetate; N,N-dimethyl-formamide; isopropyl alcohol;
DOI:10.1021/jm00045a003