2-(4-ethanesulfonyl-phenyl)-3-[4-(2-piperidin-1-yl-ethoxy)-phenoxy]-benzo[b]thiophen-6-ol

Base Information

Chemical Name:2-(4-ethanesulfonyl-phenyl)-3-[4-(2-piperidin-1-yl-ethoxy)-phenoxy]-benzo[b]thiophen-6-ol
CAS No.:648906-06-3
Molecular Formula:C₂₉H₃₁NO₅S₂
Molecular Weight:537.701
Hs Code.:

Synonyms:2-(4-ethanesulfonyl-phenyl)-3-[4-(2-piperidin-1-yl-ethoxy)-phenoxy]-benzo[b]thiophen-6-ol

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Chemical Property of 2-(4-ethanesulfonyl-phenyl)-3-[4-(2-piperidin-1-yl-ethoxy)-phenoxy]-benzo[b]thiophen-6-ol

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Technology Process of 2-(4-ethanesulfonyl-phenyl)-3-[4-(2-piperidin-1-yl-ethoxy)-phenoxy]-benzo[b]thiophen-6-ol

There total 10 articles about 2-(4-ethanesulfonyl-phenyl)-3-[4-(2-piperidin-1-yl-ethoxy)-phenoxy]-benzo[b]thiophen-6-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 648906-05-2
1-(2-{4-[6-benzyloxy-2-(4-ethanesulfonyl-phenyl)-benzo[b]thiophen-3-yloxy]-phenoxy}-ethyl)-piperidine

: 648906-06-3
2-(4-ethanesulfonyl-phenyl)-3-[4-(2-piperidin-1-yl-ethoxy)-phenoxy]-benzo[b]thiophen-6-ol

Guidance literature:: With ammonium formate; palladium dihydroxide; In methanol; ethyl acetate; for 5h; Heating / reflux;

Reference yield:

: 648906-01-8
2,3-dibromo-benzo[b]thiophen-6-ol

: 648906-06-3
2-(4-ethanesulfonyl-phenyl)-3-[4-(2-piperidin-1-yl-ethoxy)-phenoxy]-benzo[b]thiophen-6-ol

Guidance literature:: Multi-step reaction with 6 steps

1: NaH

2: 62 percent / hydrogen peroxide; TFA

3: t-BuOK / tetrahydrofuran

4: aq. TiCl₃ / methanol; CHCl₃

5: PCy₃; CsF / Pd(OAc)2

6: NH₄HCO₂ / Pd(OH)2

With titanium(III) chloride; potassium tert-butylate; dihydrogen peroxide; ammonium formate; sodium hydride; cesium fluoride; trifluoroacetic acid; tricyclohexylphosphine; palladium diacetate; palladium dihydroxide; In tetrahydrofuran; methanol; chloroform; 5: Suzuki coupling;
DOI:10.1016/j.bmcl.2007.04.044

Reference yield:

: 648906-00-7
2,2-dimethyl-propionic acid 2,3-dibromo-benzo[b]thiophen-6-yl ester

: 648906-06-3
2-(4-ethanesulfonyl-phenyl)-3-[4-(2-piperidin-1-yl-ethoxy)-phenoxy]-benzo[b]thiophen-6-ol

Guidance literature:: Multi-step reaction with 7 steps

1: KOH

2: NaH

3: 62 percent / hydrogen peroxide; TFA

4: t-BuOK / tetrahydrofuran

5: aq. TiCl₃ / methanol; CHCl₃

6: PCy₃; CsF / Pd(OAc)2

7: NH₄HCO₂ / Pd(OH)2

With potassium hydroxide; titanium(III) chloride; potassium tert-butylate; dihydrogen peroxide; ammonium formate; sodium hydride; cesium fluoride; trifluoroacetic acid; tricyclohexylphosphine; palladium diacetate; palladium dihydroxide; In tetrahydrofuran; methanol; chloroform; 6: Suzuki coupling;
DOI:10.1016/j.bmcl.2007.04.044