(4-benzyl-piperazin-1-yl)-(2-trifluoromethyl-phenyl)-methanone

Base Information

• Chemical Name: (4-benzyl-piperazin-1-yl)-(2-trifluoromethyl-phenyl)-methanone
• CAS No.: 948670-83-5
• Molecular Formula: C₁₉H₁₉F₃N₂O
• Molecular Weight: 348.368
• Mol file: 948670-83-5.mol

Synonyms:(4-benzyl-piperazin-1-yl)-(2-trifluoromethyl-phenyl)-methanone

Chemical Property of (4-benzyl-piperazin-1-yl)-(2-trifluoromethyl-phenyl)-methanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

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Technology Process of (4-benzyl-piperazin-1-yl)-(2-trifluoromethyl-phenyl)-methanone

There total 1 articles about (4-benzyl-piperazin-1-yl)-(2-trifluoromethyl-phenyl)-methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

1-phenylmethylpiperazine (2759-28-6) + 2-trifluoromethylbenzoic acid (433-97-6) → (4-benzyl-piperazin-1-yl)-(2-trifluoromethyl-phenyl)-methanone (948670-83-5)

Guidance literature:

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 10 - 20 ℃;

Reference yield: 86.0%

(4-benzyl-piperazin-1-yl)-(2-trifluoromethyl-phenyl)-methanone (948670-83-5) → piperazine-1-yl-(2-trifluoromethylphenyl)methanone (179534-78-2)

Guidance literature:

With ammonium formate; palladium 10% on activated carbon; In methanol; water; at 75 ℃; for 4h;

upstream raw materials:

1-phenylmethylpiperazine

2-trifluoromethylbenzoic acid

Downstream raw materials:

piperazine-1-yl-(2-trifluoromethylphenyl)methanone