5-({5-[4-((2R,3R,4S,5S,6S)-3,4,5-Triacetoxy-6-methoxycarbonyl-tetrahydro-pyran-2-yloxy)-butyrylamino]-1H-indole-2-carbonyl}-amino)-1H-indole-2-carboxylic acid benzyl ester

Base Information

Chemical Name:5-({5-[4-((2R,3R,4S,5S,6S)-3,4,5-Triacetoxy-6-methoxycarbonyl-tetrahydro-pyran-2-yloxy)-butyrylamino]-1H-indole-2-carbonyl}-amino)-1H-indole-2-carboxylic acid benzyl ester
CAS No.:199806-27-4
Molecular Formula:C₄₂H₄₂N₄O₁₄
Molecular Weight:826.814
Hs Code.:

5-({5-[4-((2R,3R,4S,5S,6S)-3,4,5-Triacetoxy-6-methoxycarbonyl-tetrahydro-pyran-2-yloxy)-butyrylamino]-1H-indole-2-carbonyl}-amino)-1H-indole-2-carboxylic acid benzyl ester

Synonyms:5-({5-[4-((2R,3R,4S,5S,6S)-3,4,5-Triacetoxy-6-methoxycarbonyl-tetrahydro-pyran-2-yloxy)-butyrylamino]-1H-indole-2-carbonyl}-amino)-1H-indole-2-carboxylic acid benzyl ester

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Chemical Property of 5-({5-[4-((2R,3R,4S,5S,6S)-3,4,5-Triacetoxy-6-methoxycarbonyl-tetrahydro-pyran-2-yloxy)-butyrylamino]-1H-indole-2-carbonyl}-amino)-1H-indole-2-carboxylic acid benzyl ester

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Technology Process of 5-({5-[4-((2R,3R,4S,5S,6S)-3,4,5-Triacetoxy-6-methoxycarbonyl-tetrahydro-pyran-2-yloxy)-butyrylamino]-1H-indole-2-carbonyl}-amino)-1H-indole-2-carboxylic acid benzyl ester

There total 9 articles about 5-({5-[4-((2R,3R,4S,5S,6S)-3,4,5-Triacetoxy-6-methoxycarbonyl-tetrahydro-pyran-2-yloxy)-butyrylamino]-1H-indole-2-carbonyl}-amino)-1H-indole-2-carboxylic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 199806-24-1
5-amino-1H-indole-2-carboxylic acid benzyl ester

: 199806-22-9
5-[4-(methyl 2,3,4-tri-O-acetyl-β-D-glucuronopyranosyl)butyramido]indole-2-carboxylic acid

: 199806-27-4
5-({5-[4-((2R,3R,4S,5S,6S)-3,4,5-Triacetoxy-6-methoxycarbonyl-tetrahydro-pyran-2-yloxy)-butyrylamino]-1H-indole-2-carbonyl}-amino)-1H-indole-2-carboxylic acid benzyl ester

Guidance literature:: With benzotriazol-1-ol; dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide; at 20 ℃; for 2h;
DOI:10.1016/S0968-0896(02)00603-X

Reference yield:

: 16732-57-3
5-nitro-indole-2-carboxylic acid ethyl ester

: 199806-27-4
5-({5-[4-((2R,3R,4S,5S,6S)-3,4,5-Triacetoxy-6-methoxycarbonyl-tetrahydro-pyran-2-yloxy)-butyrylamino]-1H-indole-2-carbonyl}-amino)-1H-indole-2-carboxylic acid benzyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: H₂ / 10 percent Pd/C / ethyl acetate / 1 h / 20 °C

2: 1.37 g / 18 h / 130 °C

3: 65 percent / 3N NaOH / methanol / 18 h / 20 °C

4: 71 percent / NaHCO₃ / dimethylformamide / 18 h / 20 °C

5: molecular sieves; AgOTf; g2CO₃ / tetrahydrofuran; CH₂Cl₂ / -60 - 20 °C

6: 846 mg / H₂ / 10 percent Pd/C / ethyl acetate / 1 h / 20 °C

7: 80 percent / DCC; HOBt / dimethylformamide / 2 h / 20 °C

With sodium hydroxide; molecular sieve; hydrogen; silver trifluoromethanesulfonate; sodium hydrogencarbonate; benzotriazol-1-ol; dicyclohexyl-carbodiimide; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1016/S0968-0896(02)00603-X

Reference yield:

: 199806-19-4
5-[(4-hydroxy)butyramido]indole-2-carboxylic acid

: 199806-27-4
5-({5-[4-((2R,3R,4S,5S,6S)-3,4,5-Triacetoxy-6-methoxycarbonyl-tetrahydro-pyran-2-yloxy)-butyrylamino]-1H-indole-2-carbonyl}-amino)-1H-indole-2-carboxylic acid benzyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 71 percent / NaHCO₃ / dimethylformamide / 18 h / 20 °C

2: molecular sieves; AgOTf; g2CO₃ / tetrahydrofuran; CH₂Cl₂ / -60 - 20 °C

3: 846 mg / H₂ / 10 percent Pd/C / ethyl acetate / 1 h / 20 °C

4: 80 percent / DCC; HOBt / dimethylformamide / 2 h / 20 °C

With molecular sieve; hydrogen; silver trifluoromethanesulfonate; sodium hydrogencarbonate; benzotriazol-1-ol; dicyclohexyl-carbodiimide; palladium on activated charcoal; In tetrahydrofuran; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1016/S0968-0896(02)00603-X