19-O,23-O-Di-(tert-butyldimethylsilyl)hydroquinone-mucocin dimethyl ether

Base Information

Chemical Name:19-O,23-O-Di-(tert-butyldimethylsilyl)hydroquinone-mucocin dimethyl ether
CAS No.:337954-04-8
Molecular Formula:C₅₅H₁₀₄O₉Si₂
Molecular Weight:965.596
Hs Code.:

Synonyms:19-O,23-O-Di-(tert-butyldimethylsilyl)hydroquinone-mucocin dimethyl ether

Suppliers and Price of 19-O,23-O-Di-(tert-butyldimethylsilyl)hydroquinone-mucocin dimethyl ether

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 19-O,23-O-Di-(tert-butyldimethylsilyl)hydroquinone-mucocin dimethyl ether

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 19-O,23-O-Di-(tert-butyldimethylsilyl)hydroquinone-mucocin dimethyl ether

There total 9 articles about 19-O,23-O-Di-(tert-butyldimethylsilyl)hydroquinone-mucocin dimethyl ether which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 237057-53-3
(2S,3R,6S,1'S)-2-Decyl-3-tert-butyldimethylsilyloxy-6-(1'-tert-butyldimethylsilyloxy-3'-iodo)propyltetrahydropyran

: 292820-08-7
(2S,5R)-2-Formyl-5-(9'-(2'',3'',4'',5''-tetramethoxy-6''-methylphenyl)nonyl)tetrahydrofuran

: (1R,4S)-4-(tert-Butyl-dimethyl-silanyloxy)-4-[(2S,5R,6S)-5-(tert-butyl-dimethyl-silanyloxy)-6-decyl-tetrahydro-pyran-2-yl]-1-{(2S,5R)-5-[9-(2,3,4,5-tetramethoxy-6-methyl-phenyl)-nonyl]-tetrahydro-furan-2-yl}-butan-1-ol

: 337954-04-8
19-O,23-O-Di-(tert-butyldimethylsilyl)hydroquinone-mucocin dimethyl ether

Guidance literature:: (2S,3R,6S,1'S)-2-Decyl-3-tert-butyldimethylsilyloxy-6-(1'-tert-butyldimethylsilyloxy-3'-iodo)propyltetrahydropyran; With tert.-butyl lithium; In diethyl ether; at -105 ℃; for 0.0666667h;

With magnesium bromide; In tetrahydrofuran; at -100 - -40 ℃; for 2h;

(2S,5R)-2-Formyl-5-(9'-(2'',3'',4'',5''-tetramethoxy-6''-methylphenyl)nonyl)tetrahydrofuran; In tetrahydrofuran; at -78 - -10 ℃; for 2h;
DOI:10.1002/1521-3773(20000616)39:12<2099::AID-ANIE2099>3.0.CO;2-Y

Reference yield:

: 292820-17-8
(2S,5R)-2-Hydroxymethyl-5-(9'-(2'',3'',4'',5''-tetramethoxy-6''-methylphenyl)nonyl)tetrahydrofuran

: 337954-04-8
19-O,23-O-Di-(tert-butyldimethylsilyl)hydroquinone-mucocin dimethyl ether

Guidance literature:: Multi-step reaction with 2 steps

1.1: 89 percent / (COCl)2; DMSO; NEt₃ / CH₂Cl₂ / 1.75 h / -78 - -35 °C

2.1: tBuLi; magnesium bromide etherate / diethyl ether / 2 h / -105 - -40 °C

2.2: diethyl ether / 2 h / -78 - -10 °C

With oxalyl dichloride; tert.-butyl lithium; magnesium bromide ethyl etherate; dimethyl sulfoxide; triethylamine; In diethyl ether; dichloromethane; 1.1: Swern oxidation;
DOI:10.1002/1521-3765(20010302)7:5<993::AID-CHEM993>3.0.CO;2-S

Reference yield:

: 292820-07-6
(2S,5R)-2-tert-Butyldiphenylsilyloxymethyl-5-(9'-(2'',3'',4'',5''-tetramethoxy-6''-methylphenyl)non-5'-enyl)tetrahydrofuran

: 337954-04-8
19-O,23-O-Di-(tert-butyldimethylsilyl)hydroquinone-mucocin dimethyl ether

Guidance literature:: Multi-step reaction with 4 steps

1.1: 97 percent / H₂ / 5percent Pt/C / ethyl acetate / 6 h / 760.05 Torr

2.1: 95 percent / TBAF / tetrahydrofuran / 2.5 h

3.1: 89 percent / (COCl)2; DMSO; NEt₃ / CH₂Cl₂ / 1.75 h / -78 - -35 °C

4.1: tBuLi; magnesium bromide etherate / diethyl ether / 2 h / -105 - -40 °C

4.2: diethyl ether / 2 h / -78 - -10 °C

With oxalyl dichloride; tetrabutyl ammonium fluoride; hydrogen; tert.-butyl lithium; magnesium bromide ethyl etherate; dimethyl sulfoxide; triethylamine; 5percent Pt/C; In tetrahydrofuran; diethyl ether; dichloromethane; ethyl acetate; 3.1: Swern oxidation;
DOI:10.1002/1521-3765(20010302)7:5<993::AID-CHEM993>3.0.CO;2-S