Technology Process of 7-O-Biotinyl-quercetin
There total 5 articles about 7-O-Biotinyl-quercetin which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
N-methyl-2-dimethylamino-acetohydroxamic acid; water;
In
tetrahydrofuran; methanol;
for 12h;
pH=7.4;
aq. phosphate buffer;
Inert atmosphere;
DOI:10.1016/j.bmc.2011.07.005
- Guidance literature:
-
Multi-step reaction with 4 steps
1: potassium carbonate; potassium iodide / acetone / 2 h / Reflux
2: trifluoroacetic acid / dichloromethane / 20 °C / Inert atmosphere
3: 1-hydroxy-pyrrolidine-2,5-dione; 4-morpholineethanesulfonic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / acetonitrile / 12 h / 20 °C / pH 5.5 / Inert atmosphere
4: N-methyl-2-dimethylamino-acetohydroxamic acid; water / tetrahydrofuran; methanol / 12 h / pH 7.4 / aq. phosphate buffer; Inert atmosphere
With
1-hydroxy-pyrrolidine-2,5-dione; 4-morpholineethanesulfonic acid; N-methyl-2-dimethylamino-acetohydroxamic acid; water; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; potassium iodide;
In
tetrahydrofuran; methanol; dichloromethane; acetone; acetonitrile;
DOI:10.1016/j.bmc.2011.07.005
- Guidance literature:
-
Multi-step reaction with 3 steps
1: trifluoroacetic acid / dichloromethane / 20 °C / Inert atmosphere
2: 1-hydroxy-pyrrolidine-2,5-dione; 4-morpholineethanesulfonic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / acetonitrile / 12 h / 20 °C / pH 5.5 / Inert atmosphere
3: N-methyl-2-dimethylamino-acetohydroxamic acid; water / tetrahydrofuran; methanol / 12 h / pH 7.4 / aq. phosphate buffer; Inert atmosphere
With
1-hydroxy-pyrrolidine-2,5-dione; 4-morpholineethanesulfonic acid; N-methyl-2-dimethylamino-acetohydroxamic acid; water; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid;
In
tetrahydrofuran; methanol; dichloromethane; acetonitrile;
DOI:10.1016/j.bmc.2011.07.005
