tert-butyl (S)-1-amino-3-(1-trityl-1H-imidazol-4-yl)propan-2-ylcarbamate

Base Information

Chemical Name:tert-butyl (S)-1-amino-3-(1-trityl-1H-imidazol-4-yl)propan-2-ylcarbamate
CAS No.:1376947-77-1
Molecular Formula:C₃₀H₃₄N₄O₂
Molecular Weight:482.626
Hs Code.:

Synonyms:tert-butyl (S)-1-amino-3-(1-trityl-1H-imidazol-4-yl)propan-2-ylcarbamate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of tert-butyl (S)-1-amino-3-(1-trityl-1H-imidazol-4-yl)propan-2-ylcarbamate

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Technology Process of tert-butyl (S)-1-amino-3-(1-trityl-1H-imidazol-4-yl)propan-2-ylcarbamate

There total 3 articles about tert-butyl (S)-1-amino-3-(1-trityl-1H-imidazol-4-yl)propan-2-ylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1376948-13-8
tert-butyl (S)-1-azido-3-(1-trityl-1H-imidazol-4-yl)propan-2-ylcarbamate

: 1376947-77-1
tert-butyl (S)-1-amino-3-(1-trityl-1H-imidazol-4-yl)propan-2-ylcarbamate

Guidance literature:: With 5% Pd-BaSO4; hydrogen; In ethyl acetate; at 20 ℃; for 20h;
DOI:10.1016/j.tet.2011.11.066

Reference yield:

: 1376948-10-5
(S)-1-azido-N-trityl-3-(1-trityl-1H-imidazol-4-yl)propan-2-amine

: 1376947-77-1
tert-butyl (S)-1-amino-3-(1-trityl-1H-imidazol-4-yl)propan-2-ylcarbamate

Guidance literature:: Multi-step reaction with 2 steps

1.1: trifluoroacetic acid / methanol; 1,2-dichloro-ethane / 0.17 h / 0 - 10 °C

1.2: 0.33 h / 20 °C

2.1: 5% Pd-BaSO4; hydrogen / ethyl acetate / 20 h / 20 °C

With 5% Pd-BaSO4; hydrogen; trifluoroacetic acid; In methanol; ethyl acetate; 1,2-dichloro-ethane;
DOI:10.1016/j.tet.2011.11.066

Reference yield:

: 223910-41-6
2-(S)-(triphenylmethylamino)-3-<1-(triphenylmethyl)imidazol-4(5)-yl>propanol ditrityl-L-histidinol

: 1376947-77-1
tert-butyl (S)-1-amino-3-(1-trityl-1H-imidazol-4-yl)propan-2-ylcarbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: diphenyl phosphoryl azide; 1,8-diazabicyclo[5.4.0]undec-7-ene / N,N-dimethyl-formamide / 5 h / 65 °C

1.2: 12 h / 65 °C

2.1: trifluoroacetic acid / methanol; 1,2-dichloro-ethane / 0.17 h / 0 - 10 °C

2.2: 0.33 h / 20 °C

3.1: 5% Pd-BaSO4; hydrogen / ethyl acetate / 20 h / 20 °C

With diphenyl phosphoryl azide; 5% Pd-BaSO4; hydrogen; 1,8-diazabicyclo[5.4.0]undec-7-ene; trifluoroacetic acid; In methanol; ethyl acetate; 1,2-dichloro-ethane; N,N-dimethyl-formamide;
DOI:10.1016/j.tet.2011.11.066