(R)-4-<<3-(1H-indol-3-yl)-2-methyl-2-<<(tricyclo<3.3.1.1^3,7>dec-2-yloxy)carbonyl>amino>propyl>(2-phenylethyl)amino>-4-oxobutanoic acid

Base Information

• Chemical Name: (R)-4-<<3-(1H-indol-3-yl)-2-methyl-2-<<(tricyclo<3.3.1.1^3,7>dec-2-yloxy)carbonyl>amino>propyl>(2-phenylethyl)amino>-4-oxobutanoic acid
• CAS No.: 139657-27-5
• Molecular Formula: C₃₅H₄₃N₃O₅
• Molecular Weight: 585.744

Synonyms:(R)-4-<<3-(1H-indol-3-yl)-2-methyl-2-<<(tricyclo<3.3.1.1^3,7>dec-2-yloxy)carbonyl>amino>propyl>(2-phenylethyl)amino>-4-oxobutanoic acid

Chemical Property of (R)-4-<<3-(1H-indol-3-yl)-2-methyl-2-<<(tricyclo<3.3.1.1^3,7>dec-2-yloxy)carbonyl>amino>propyl>(2-phenylethyl)amino>-4-oxobutanoic acid

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Technology Process of (R)-4-<<3-(1H-indol-3-yl)-2-methyl-2-<<(tricyclo<3.3.1.1^3,7>dec-2-yloxy)carbonyl>amino>propyl>(2-phenylethyl)amino>-4-oxobutanoic acid

There total 3 articles about (R)-4-<<3-(1H-indol-3-yl)-2-methyl-2-<<(tricyclo<3.3.1.1^3,7>dec-2-yloxy)carbonyl>amino>propyl>(2-phenylethyl)amino>-4-oxobutanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

ethyl (R)-4-<<3-(1H-indol-3-yl)-2-methyl-2-<<(tricyclo<3.3.1.13,7>dec-2-yloxy)carbonyl>amino>propyl>(2-phenylethyl)amino>-4-oxobutanoate (139657-26-4) → (R)-4-<<3-(1H-indol-3-yl)-2-methyl-2-<<(tricyclo<3.3.1.13,7>dec-2-yloxy)carbonyl>amino>propyl>(2-phenylethyl)amino>-4-oxobutanoic acid (139657-27-5)

Guidance literature:

With lithium hydroxide; In tetrahydrofuran; methanol; water; for 0.666667h; Ambient temperature;

DOI:10.1021/jm00086a017

Reference yield:

tricyclo[3.3.1.13,7]dec-2-yl (R)-{1-(1H-indol-3-ylmethyl)-1-methyl-2-oxo-2-[(2-phenylethyl)amino]ethyl}carbamate (130406-43-8) → (R)-4-<<3-(1H-indol-3-yl)-2-methyl-2-<<(tricyclo<3.3.1.13,7>dec-2-yloxy)carbonyl>amino>propyl>(2-phenylethyl)amino>-4-oxobutanoic acid (139657-27-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 14 percent / lithium borohydride, chlorotrimethylsilane / tetrahydrofuran / 20 h / Ambient temperature

2: 81 percent / triethylamine / CH₂Cl₂ / 0.33 h / 0 °C

3: 81 percent / lithium hydroxide monohydrate / tetrahydrofuran; methanol; H₂O / 0.67 h / Ambient temperature

With lithium hydroxide; lithium borohydride; chloro-trimethyl-silane; triethylamine; In tetrahydrofuran; methanol; dichloromethane; water;

DOI:10.1021/jm00086a017

Reference yield:

tricyclo<3.3.1.13,7>dec-2-yl <1-(1H-indol-3-ylmethyl)-1-methyl-2-<(2-phenylethyl)amino>ethyl>carbamate (139657-24-2) → (R)-4-<<3-(1H-indol-3-yl)-2-methyl-2-<<(tricyclo<3.3.1.13,7>dec-2-yloxy)carbonyl>amino>propyl>(2-phenylethyl)amino>-4-oxobutanoic acid (139657-27-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 81 percent / triethylamine / CH₂Cl₂ / 0.33 h / 0 °C

2: 81 percent / lithium hydroxide monohydrate / tetrahydrofuran; methanol; H₂O / 0.67 h / Ambient temperature

With lithium hydroxide; triethylamine; In tetrahydrofuran; methanol; dichloromethane; water;

DOI:10.1021/jm00086a017

upstream raw materials:

ethyl (R)-4-<<3-(1H-indol-3-yl)-2-methyl-2-<<(tricyclo<3.3.1.1^3,7>dec-2-yloxy)carbonyl>amino>propyl>(2-phenylethyl)amino>-4-oxobutanoate

tricyclo[3.3.1.1^3,7]dec-2-yl (R)-{1-(1H-indol-3-ylmethyl)-1-methyl-2-oxo-2-[(2-phenylethyl)amino]ethyl}carbamate

tricyclo<3.3.1.1^3,7>dec-2-yl <1-(1H-indol-3-ylmethyl)-1-methyl-2-<(2-phenylethyl)amino>ethyl>carbamate

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