C₂₅H₃₄F₂N₄O₄

Base Information

Chemical Name:C₂₅H₃₄F₂N₄O₄
CAS No.:1271778-08-5
Molecular Formula:C₂₅H₃₄F₂N₄O₄
Molecular Weight:492.566
Hs Code.:

C<sub>25</sub>H<sub>34</sub>F<sub>2</sub>N<sub>4</sub>O<sub>4</sub>

Synonyms:C₂₅H₃₄F₂N₄O₄

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of C₂₅H₃₄F₂N₄O₄

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Technology Process of C₂₅H₃₄F₂N₄O₄

There total 16 articles about C₂₅H₃₄F₂N₄O₄ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1271778-06-3
C₃₅H₅₀F₂N₄O₈

: 1271778-08-5
C₂₅H₃₄F₂N₄O₄

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 0 - 20 ℃; for 20.25h; Inert atmosphere;

Reference yield:

: 32133-38-3,266360-61-6
2,5-difluoro-DL-phenylalanine

: 1271778-08-5
C₂₅H₃₄F₂N₄O₄

Guidance literature:: Multi-step reaction with 10 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / 6 h / 0 °C / Reflux

2.1: dichloromethane / 20 °C

3.1: triethylamine / dichloromethane / 0 °C

4.1: N,N-dimethyl-formamide / 18 h / 60 °C

5.1: sodium hydroxide; water / 6 h / Reflux

5.2: 20 °C

6.1: dicyclohexyl-carbodiimide; benzotriazol-1-ol / dichloromethane / 1 h / 0 °C

6.2: 18 h / 20 °C

7.1: dicyclohexyl-carbodiimide; benzotriazol-1-ol / dichloromethane / 1 h / 0 °C / Inert atmosphere

7.2: 6.25 h / 0 - 20 °C

8.1: tert.-butyl lithium / pentane; tetrahydrofuran / 0.5 h / -78 - -20 °C / Inert atmosphere

8.2: 0.67 h / -78 - 20 °C

9.1: caesium carbonate / methanol / 22 h / 20 °C / Inert atmosphere

10.1: trifluoroacetic acid / dichloromethane / 20.25 h / 0 - 20 °C / Inert atmosphere

With lithium aluminium tetrahydride; water; tert.-butyl lithium; benzotriazol-1-ol; caesium carbonate; triethylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; pentane;

Reference yield:

: 1271774-61-8
C₂₀H₃₁F₂N₃O₃

: 1271778-08-5
C₂₅H₃₄F₂N₄O₄

Guidance literature:: Multi-step reaction with 4 steps

1.1: dicyclohexyl-carbodiimide; benzotriazol-1-ol / dichloromethane / 1 h / 0 °C / Inert atmosphere

1.2: 6.25 h / 0 - 20 °C

2.1: tert.-butyl lithium / pentane; tetrahydrofuran / 0.5 h / -78 - -20 °C / Inert atmosphere

2.2: 0.67 h / -78 - 20 °C

3.1: caesium carbonate / methanol / 22 h / 20 °C / Inert atmosphere

4.1: trifluoroacetic acid / dichloromethane / 20.25 h / 0 - 20 °C / Inert atmosphere

With tert.-butyl lithium; benzotriazol-1-ol; caesium carbonate; dicyclohexyl-carbodiimide; trifluoroacetic acid; In tetrahydrofuran; methanol; dichloromethane; pentane;