1-methyl-2-cyano-2-deuterio-3-ethyl-4-thiophenylpiperidine

Base Information

Chemical Name:1-methyl-2-cyano-2-deuterio-3-ethyl-4-thiophenylpiperidine
CAS No.:73658-14-7
Molecular Formula:C₁₅H₂₀N₂S
Molecular Weight:261.395
Hs Code.:

Synonyms:1-methyl-2-cyano-2-deuterio-3-ethyl-4-thiophenylpiperidine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-methyl-2-cyano-2-deuterio-3-ethyl-4-thiophenylpiperidine

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Technology Process of 1-methyl-2-cyano-2-deuterio-3-ethyl-4-thiophenylpiperidine

There total 7 articles about 1-methyl-2-cyano-2-deuterio-3-ethyl-4-thiophenylpiperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 73657-77-9
1-methyl-2-cyano-3-ethyl-4-thiophenylpiperidine

: 73658-14-7
1-methyl-2-cyano-2-deuterio-3-ethyl-4-thiophenylpiperidine

Guidance literature:: With n-butyllithium; water-d2; In tetrahydrofuran; 1.) -20 deg C, 5 min, 2.) room temperature, 30 min;
DOI:10.1021/ja00523a026

Reference yield:

: 5562-30-1
1-methyl-3-ethyl-1,2,5,6-tetrahydropyridine

: 73658-14-7
1-methyl-2-cyano-2-deuterio-3-ethyl-4-thiophenylpiperidine

Guidance literature:: Multi-step reaction with 5 steps

1: 30percent hydrogen peroxide / ethanol / 60 °C

2: CH₂Cl₂ / 1.) 0 deg C, 1 h, 2.) room temperature, 15 min

3: sodium hydroxide / H₂O; CH₂Cl₂ / 1.) 1 h, 2.) 20 min, room temperature

4: 1.) CF₃COOH, 2.) KCN / 1.) methylene chloride, room temperature, 10 min, 2.) water, 1 h

5: 98 percent / n-butyllithium, D₂O / tetrahydrofuran / 1.) -20 deg C, 5 min, 2.) room temperature, 30 min

With potassium cyanide; sodium hydroxide; n-butyllithium; dihydrogen peroxide; water-d2; trifluoroacetic acid; In tetrahydrofuran; ethanol; dichloromethane; water;
DOI:10.1021/ja00523a026

Reference yield:

: 60900-17-6
1-methyl-3-ethyl-1,2,5,6-tetrahydropyridine N-oxide

: 73658-14-7
1-methyl-2-cyano-2-deuterio-3-ethyl-4-thiophenylpiperidine

Guidance literature:: Multi-step reaction with 4 steps

1: CH₂Cl₂ / 1.) 0 deg C, 1 h, 2.) room temperature, 15 min

2: sodium hydroxide / H₂O; CH₂Cl₂ / 1.) 1 h, 2.) 20 min, room temperature

3: 1.) CF₃COOH, 2.) KCN / 1.) methylene chloride, room temperature, 10 min, 2.) water, 1 h

4: 98 percent / n-butyllithium, D₂O / tetrahydrofuran / 1.) -20 deg C, 5 min, 2.) room temperature, 30 min

With potassium cyanide; sodium hydroxide; n-butyllithium; water-d2; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; water;
DOI:10.1021/ja00523a026