Benzo[b]thiophene-3-carbonyl chloride

Base Information

• Chemical Name: Benzo[b]thiophene-3-carbonyl chloride
• CAS No.: 39827-12-8
• Molecular Formula: C9H5 Cl O S
• Molecular Weight: 196.657
• Hs Code.: 29339900
• European Community (EC) Number: 692-237-7
• DSSTox Substance ID: DTXSID30379998
• Nikkaji Number: J89.313G
• Wikidata: Q82170025
• ChEMBL ID: CHEMBL3358214
• Mol file: 39827-12-8.mol

Synonyms:39827-12-8;Benzo[b]thiophene-3-carbonyl chloride;1-benzothiophene-3-carbonyl chloride;Benzothiophene-3-carbonyl chloride;CHEMBL3358214;Benzo[b]thiophene-3-carbonylchloride;benzothiophene-3-carboxylic acid chloride;SCHEMBL645673;DTXSID30379998;GSMXWLPUJAYDHX-UHFFFAOYSA-N;BDBM50037881;MFCD02682005;AKOS005172552;FS-5875;SB67090;1-benzo[b]thiophene-3-carbonyl chloride;FT-0607374;1-benzothiophene-3-carbonyl chloride, AldrichCPR;A824754;J-504230

Chemical Property of Benzo[b]thiophene-3-carbonyl chloride

Chemical Property:

• Vapor Pressure: 0.000636mmHg at 25°C
• Boiling Point: 309.5°Cat760mmHg
• Flash Point: 141°C
• PSA: 45.31000
• Density: 1.41g/cm³
• LogP: 3.28030
• XLogP3: 3.6
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 195.9749636
• Heavy Atom Count: 12
• Complexity: 195

Purity/Quality:

97% ^*data from raw suppliers

1-Benzothiophene-3-carbonylChloride ^*data from reagent suppliers

Safty Information:

• Hazard Codes: C,Xi
• Statements: 34-36
• Safety Statements: 26-36/37/39-45

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C2C(=C1)C(=CS2)C(=O)Cl
• General Description: **1-Benzothiophene-3-carbonyl chloride (also known as 3-benzothiophenecarbonylchloride)** is a reactive intermediate used in the synthesis of pharmacologically active benzo[b]thiophene derivatives, including local anesthetics, anticholinergics, and antihistaminics. It serves as a key precursor for constructing amides, esters, and ureas with potential therapeutic applications. Additionally, its derivatives have been explored in anion-binding and transport studies, demonstrating utility in developing drug-like molecules with selective biological activity. 1-BENZOTHIOPHENE-3-CARBONYL CHLORIDE's versatility in organic synthesis and medicinal chemistry highlights its importance as a building block for bioactive heterocycles.

Technology Process of Benzo[b]thiophene-3-carbonyl chloride

There total 4 articles about Benzo[b]thiophene-3-carbonyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

benzo[b]thiophene-3-carboxylic acid (5381-25-9) → benzothiophene-3-carbonyl chloride (39827-12-8)

Guidance literature:

With thionyl chloride; for 4h; Heating;

DOI:10.1002/jps.2600720228

Reference yield:

benzothiophene-3-carboxaldehyde (5381-20-4) → benzothiophene-3-carbonyl chloride (39827-12-8)

Guidance literature:

Multi-step reaction with 2 steps

1: aq. NaClO₂; NaH₂PO₄; 2-methyl-2-butene / acetone

2: (COCl)2; DMF / toluene / 3 h / 20 °C

With sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene; oxalyl dichloride; N,N-dimethyl-formamide; In acetone; toluene;

DOI:10.1055/s-2002-35577

Reference yield:

3-Bromothianaphthene (7342-82-7) → benzothiophene-3-carbonyl chloride (39827-12-8)

Guidance literature:

Multi-step reaction with 3 steps

1.1: nBuLi / diethyl ether / -78 °C

1.2: diethyl ether / -78 °C

2.1: aq. NaClO₂; NaH₂PO₄; 2-methyl-2-butene / acetone

3.1: (COCl)2; DMF / toluene / 3 h / 20 °C

With sodium chlorite; sodium dihydrogenphosphate; n-butyllithium; 2-methyl-but-2-ene; oxalyl dichloride; N,N-dimethyl-formamide; In diethyl ether; acetone; toluene;

DOI:10.1055/s-2002-35577

upstream raw materials:

benzo[b]thiophene-3-carboxylic acid

benzothiophene-3-carboxaldehyde

3-Bromothianaphthene

Downstream raw materials:

3-acetylbenzothiophene

N-phenylbenzo[b]thiophene-3-carboxamide

ethyl 2-(4-(benzo[b]thiophene-3-carboxamido)-2-(3,4-dimethoxybenzoyl)phenylamino)-2-oxoacetate

ethyl 2-(4-(benzo[b]thiophene-3-carboxamido)-2-benzoylphenylamino)-2-oxoacetate