4-(3-(3-nitrophenyl)piperazin-1-yl)-7-tosyl-7H-pyrrolo[2,3-d]pyrimidine

Base Information

Chemical Name:4-(3-(3-nitrophenyl)piperazin-1-yl)-7-tosyl-7H-pyrrolo[2,3-d]pyrimidine
CAS No.:1271809-52-9
Molecular Formula:C₂₃H₂₂N₆O₄S
Molecular Weight:478.531
Hs Code.:

Synonyms:4-(3-(3-nitrophenyl)piperazin-1-yl)-7-tosyl-7H-pyrrolo[2,3-d]pyrimidine

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Chemical Property of 4-(3-(3-nitrophenyl)piperazin-1-yl)-7-tosyl-7H-pyrrolo[2,3-d]pyrimidine

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Technology Process of 4-(3-(3-nitrophenyl)piperazin-1-yl)-7-tosyl-7H-pyrrolo[2,3-d]pyrimidine

There total 2 articles about 4-(3-(3-nitrophenyl)piperazin-1-yl)-7-tosyl-7H-pyrrolo[2,3-d]pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 479633-63-1
4-chloro-7-[(4-methylphenyl)sulfonyl]-7H-pyrrolo[2,3-d]pyrimidine

: 65709-29-7
2-(3-nitrophenyl)-piperazine

: 1271809-52-9
4-(3-(3-nitrophenyl)piperazin-1-yl)-7-tosyl-7H-pyrrolo[2,3-d]pyrimidine

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 100 ℃; for 12h;

Reference yield:

: 98-59-9
p-toluenesulfonyl chloride

: 1271809-52-9
4-(3-(3-nitrophenyl)piperazin-1-yl)-7-tosyl-7H-pyrrolo[2,3-d]pyrimidine

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydroxide / water; acetone / 10 h / 20 °C

2: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 4 h / Heating

With N-ethyl-N,N-diisopropylamine; sodium hydroxide; In water; N,N-dimethyl-formamide; acetone;
DOI:10.1016/j.bmc.2019.05.021

Reference yield:

: 1271809-52-9
4-(3-(3-nitrophenyl)piperazin-1-yl)-7-tosyl-7H-pyrrolo[2,3-d]pyrimidine

: 1271809-56-3
3-(1-(2-((tert-butyldimethylsilyl)oxy)ethyl)-4-(7-tosyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperazin-2-yl)aniline

Guidance literature:: Multi-step reaction with 2 steps

1: sodium cyanoborohydride / acetic acid / methanol / 60 °C / pH 6

2: hydrogen / palladium 10% on activated carbon / methanol / 3 h

With hydrogen; sodium cyanoborohydride; palladium 10% on activated carbon; acetic acid; In methanol;