(2S,5R,6S)-tert-butyl-2-(tert-butyldimethylsilyloxy)-4-(1-(4-methoxybenzyloxy)propan-2-ylamino)-3-methyl-4-oxobutyl(methyl)carbamate

Base Information

Chemical Name:(2S,5R,6S)-tert-butyl-2-(tert-butyldimethylsilyloxy)-4-(1-(4-methoxybenzyloxy)propan-2-ylamino)-3-methyl-4-oxobutyl(methyl)carbamate
CAS No.:1255212-78-2
Molecular Formula:C₂₈H₅₀N₂O₆Si
Molecular Weight:538.8
Hs Code.:

Synonyms:(2S,5R,6S)-tert-butyl-2-(tert-butyldimethylsilyloxy)-4-(1-(4-methoxybenzyloxy)propan-2-ylamino)-3-methyl-4-oxobutyl(methyl)carbamate

Suppliers and Price of (2S,5R,6S)-tert-butyl-2-(tert-butyldimethylsilyloxy)-4-(1-(4-methoxybenzyloxy)propan-2-ylamino)-3-methyl-4-oxobutyl(methyl)carbamate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (2S,5R,6S)-tert-butyl-2-(tert-butyldimethylsilyloxy)-4-(1-(4-methoxybenzyloxy)propan-2-ylamino)-3-methyl-4-oxobutyl(methyl)carbamate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (2S,5R,6S)-tert-butyl-2-(tert-butyldimethylsilyloxy)-4-(1-(4-methoxybenzyloxy)propan-2-ylamino)-3-methyl-4-oxobutyl(methyl)carbamate

There total 8 articles about (2S,5R,6S)-tert-butyl-2-(tert-butyldimethylsilyloxy)-4-(1-(4-methoxybenzyloxy)propan-2-ylamino)-3-methyl-4-oxobutyl(methyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 149198-42-5
(2S)-1-[(4-methoxyphenyl)methoxy]propan-2-amine

: 1255212-69-1
(2R,3S)-4-(tert-butoxycarbonyl(methyl)amino)-3-(tert-butyldimethylsilyloxy)-2-methylbutanoic acid

: 1255212-78-2
(2S,5R,6S)-tert-butyl-2-(tert-butyldimethylsilyloxy)-4-(1-(4-methoxybenzyloxy)propan-2-ylamino)-3-methyl-4-oxobutyl(methyl)carbamate

Guidance literature:: With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 - 20 ℃; Inert atmosphere;
DOI:10.1021/ja105119r

Reference yield: 70.0%

: 1255212-78-2
(2S,5R,6S)-tert-butyl-2-(tert-butyldimethylsilyloxy)-4-(1-(4-methoxybenzyloxy)propan-2-ylamino)-3-methyl-4-oxobutyl(methyl)carbamate

Guidance literature:: With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 3 - 5 ℃; for 15h; Inert atmosphere;

Reference yield:

: 1255212-57-7
(1R,2S)-1-phenyl-2-(N,2,4,6-tetramethylphenylsulfonamido)propyl (2R,3S)-4-(tert-butoxycarbonyl(methyl)amino)-3-hydroxy-2-methylbutanoate

: 1255212-78-2
(2S,5R,6S)-tert-butyl-2-(tert-butyldimethylsilyloxy)-4-(1-(4-methoxybenzyloxy)propan-2-ylamino)-3-methyl-4-oxobutyl(methyl)carbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: water; dihydrogen peroxide; sodium hydroxide / methanol; tert-butyl alcohol / 0 - 20 °C

1.2: pH 4

2.1: 2,6-dimethylpyridine / dichloromethane / 1 h / -78 °C / Inert atmosphere

3.1: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 0 - 20 °C / Inert atmosphere

With 2,6-dimethylpyridine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; water; dihydrogen peroxide; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In methanol; dichloromethane; tert-butyl alcohol;
DOI:10.1021/ja105119r