methyl 1-{4-(tert-butoxycarbonylamino)phenylcarbonyl}isoquinolin-4-ylcarboxylate

Base Information

Chemical Name:methyl 1-{4-(tert-butoxycarbonylamino)phenylcarbonyl}isoquinolin-4-ylcarboxylate
CAS No.:1233249-36-9
Molecular Formula:C₂₃H₂₂N₂O₅
Molecular Weight:406.438
Hs Code.:

Synonyms:methyl 1-{4-(tert-butoxycarbonylamino)phenylcarbonyl}isoquinolin-4-ylcarboxylate

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Chemical Property of methyl 1-{4-(tert-butoxycarbonylamino)phenylcarbonyl}isoquinolin-4-ylcarboxylate

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Technology Process of methyl 1-{4-(tert-butoxycarbonylamino)phenylcarbonyl}isoquinolin-4-ylcarboxylate

There total 5 articles about methyl 1-{4-(tert-butoxycarbonylamino)phenylcarbonyl}isoquinolin-4-ylcarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: 1233249-35-8
4-tert-butoxycarbonylaminophenylacetonitrile

: 37497-86-2
1-chloro-isoquinoline-4-carboxylic acid methyl ester

: 1233249-36-9
methyl 1-{4-(tert-butoxycarbonylamino)phenylcarbonyl}isoquinolin-4-ylcarboxylate

Guidance literature:: 4-tert-butoxycarbonylaminophenylacetonitrile; With sodium hexamethyldisilazane; In tetrahydrofuran; at 0 ℃; for 0.5h;

1-chloro-isoquinoline-4-carboxylic acid methyl ester; With oxygen; In tetrahydrofuran; at 20 ℃; for 19.5h;
DOI:10.1016/j.bmc.2013.10.025

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 1233249-36-9
methyl 1-{4-(tert-butoxycarbonylamino)phenylcarbonyl}isoquinolin-4-ylcarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: ethanol / 2 h / 20 °C

2.1: sodium hexamethyldisilazane / tetrahydrofuran / 0.5 h / Cooling with ice

2.2: 2.5 h / 20 °C / Cooling with ice

2.3: 17 h / 20 °C

With sodium hexamethyldisilazane; In tetrahydrofuran; ethanol;

Reference yield:

: 3544-25-0
p-aminophenylacetonitrile

: 1233249-36-9
methyl 1-{4-(tert-butoxycarbonylamino)phenylcarbonyl}isoquinolin-4-ylcarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: ethanol / 2 h / 20 °C

2.1: sodium hexamethyldisilazane / tetrahydrofuran / 0.5 h / Cooling with ice

2.2: 2.5 h / 20 °C / Cooling with ice

2.3: 17 h / 20 °C

With sodium hexamethyldisilazane; In tetrahydrofuran; ethanol;