di-tert-butyl {2-(2-chloro-6-fluorophenyl)-5-[1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl]-1H-pyrrolo[3,2-b]pyridin-1-yl}methyl phosphate

Base Information

• Chemical Name: di-tert-butyl {2-(2-chloro-6-fluorophenyl)-5-[1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl]-1H-pyrrolo[3,2-b]pyridin-1-yl}methyl phosphate
• CAS No.: 1612288-98-8
• Molecular Formula: C₂₇H₃₀ClF₄N₄O₄P
• Molecular Weight: 616.98
• Mol file: 1612288-98-8.mol

Synonyms:di-tert-butyl {2-(2-chloro-6-fluorophenyl)-5-[1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl]-1H-pyrrolo[3,2-b]pyridin-1-yl}methyl phosphate

Chemical Property of di-tert-butyl {2-(2-chloro-6-fluorophenyl)-5-[1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl]-1H-pyrrolo[3,2-b]pyridin-1-yl}methyl phosphate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of di-tert-butyl {2-(2-chloro-6-fluorophenyl)-5-[1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl]-1H-pyrrolo[3,2-b]pyridin-1-yl}methyl phosphate

There total 1 articles about di-tert-butyl {2-(2-chloro-6-fluorophenyl)-5-[1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl]-1H-pyrrolo[3,2-b]pyridin-1-yl}methyl phosphate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

2-(2-chloro-6-fluorophenyl)-5-[1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl]-1H-pyrrolo[3,2-b]pyridine (1443732-64-6) + di-tert-butyl chloromethyl phosphate (229625-50-7) → di-tert-butyl {2-(2-chloro-6-fluorophenyl)-5-[1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl]-1H-pyrrolo[3,2-b]pyridin-1-yl}methyl phosphate (1612288-98-8)

Guidance literature:

2-(2-chloro-6-fluorophenyl)-5-[1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl]-1H-pyrrolo[3,2-b]pyridine; With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃; for 0.333333h;

di-tert-butyl chloromethyl phosphate; With sodium iodide; In N,N-dimethyl-formamide; at 60 ℃; for 2.5h;

Reference yield: 76.0%

di-tert-butyl {2-(2-chloro-6-fluorophenyl)-5-[1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl]-1H-pyrrolo[3,2-b]pyridin-1-yl}methyl phosphate (1612288-98-8) → {2-(2-chloro-6-fluorophenyl)-5-[1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl]-1H-pyrrolo[3,2-b]pyridin-1-yl}methyl dihydrogen phosphate (1612288-97-7)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 0.666667h;

upstream raw materials:

2-(2-chloro-6-fluorophenyl)-5-[1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl]-1H-pyrrolo[3,2-b]pyridine

di-tert-butyl chloromethyl phosphate

Downstream raw materials:

{2-(2-chloro-6-fluorophenyl)-5-[1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl]-1H-pyrrolo[3,2-b]pyridin-1-yl}methyl dihydrogen phosphate