tert-butyl 1,1,1-trifluoro-3-oxo-3-(2-(phenylcarbamoyl)-1H-pyrrol-1-ylamino)propan-2-ylcarbamate

Base Information

Chemical Name:tert-butyl 1,1,1-trifluoro-3-oxo-3-(2-(phenylcarbamoyl)-1H-pyrrol-1-ylamino)propan-2-ylcarbamate
CAS No.:1403943-20-3
Molecular Formula:C₁₉H₂₁F₃N₄O₄
Molecular Weight:426.395
Hs Code.:

Synonyms:tert-butyl 1,1,1-trifluoro-3-oxo-3-(2-(phenylcarbamoyl)-1H-pyrrol-1-ylamino)propan-2-ylcarbamate

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Chemical Property of tert-butyl 1,1,1-trifluoro-3-oxo-3-(2-(phenylcarbamoyl)-1H-pyrrol-1-ylamino)propan-2-ylcarbamate

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Technology Process of tert-butyl 1,1,1-trifluoro-3-oxo-3-(2-(phenylcarbamoyl)-1H-pyrrol-1-ylamino)propan-2-ylcarbamate

There total 1 articles about tert-butyl 1,1,1-trifluoro-3-oxo-3-(2-(phenylcarbamoyl)-1H-pyrrol-1-ylamino)propan-2-ylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

: 188030-43-5
2-{[(tert-butoxy)carbonyl]amino}-3,3,3-trifluoropropanoic acid

: 1403942-10-8
1-amino-N-phenyl-1H-pyrrole-2-carboxamide

: 1403943-20-3
tert-butyl 1,1,1-trifluoro-3-oxo-3-(2-(phenylcarbamoyl)-1H-pyrrol-1-ylamino)propan-2-ylcarbamate

Guidance literature:: With 4-methyl-morpholine; HATU; In dichloromethane;

Reference yield: 41.0%

: 1403943-20-3
tert-butyl 1,1,1-trifluoro-3-oxo-3-(2-(phenylcarbamoyl)-1H-pyrrol-1-ylamino)propan-2-ylcarbamate

: 1403943-21-4
tert-butyl 2,2,2-trifluoro-1-(4-oxo-3-phenyl-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)ethylcarbamate

Guidance literature:: tert-butyl 1,1,1-trifluoro-3-oxo-3-(2-(phenylcarbamoyl)-1H-pyrrol-1-ylamino)propan-2-ylcarbamate; With bromine; triethylamine; triphenylphosphine; In dichloromethane; at 40 ℃; for 75h;

With sodium thiomethoxide; In methanol; N,N-dimethyl-formamide; at 20 - 60 ℃;

Reference yield:

: 1403943-20-3
tert-butyl 1,1,1-trifluoro-3-oxo-3-(2-(phenylcarbamoyl)-1H-pyrrol-1-ylamino)propan-2-ylcarbamate

: 1403943-22-5
3-phenyl-2-(2,2,2-trifluoro-1-(9-(4-methoxybenzyl)-9H-purin-6-ylamino)ethyl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine; triphenylphosphine; bromine / dichloromethane / 75 h / 40 °C

1.2: 20 - 60 °C

2.1: trifluoroacetic acid / dichloromethane / 3 h / 20 °C

3.1: caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / palladium diacetate / toluene / 120 °C / Inert atmosphere

With bromine; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; triethylamine; triphenylphosphine; trifluoroacetic acid; palladium diacetate; In dichloromethane; toluene;