N-(2-fluoro-4-{5-[2-(methoxymethyl)-2’-methylbiphenyl-4-yl]-1,2,4-oxadiazol-3-yl}benzoyl)-β-alanine

Base Information

Chemical Name:N-(2-fluoro-4-{5-[2-(methoxymethyl)-2’-methylbiphenyl-4-yl]-1,2,4-oxadiazol-3-yl}benzoyl)-β-alanine
CAS No.:1141472-91-4
Molecular Formula:C₂₇H₂₄FN₃O₅
Molecular Weight:489.503
Hs Code.:

Synonyms:N-(2-fluoro-4-{5-[2-(methoxymethyl)-2’-methylbiphenyl-4-yl]-1,2,4-oxadiazol-3-yl}benzoyl)-β-alanine

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Chemical Property of N-(2-fluoro-4-{5-[2-(methoxymethyl)-2’-methylbiphenyl-4-yl]-1,2,4-oxadiazol-3-yl}benzoyl)-β-alanine

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Technology Process of N-(2-fluoro-4-{5-[2-(methoxymethyl)-2’-methylbiphenyl-4-yl]-1,2,4-oxadiazol-3-yl}benzoyl)-β-alanine

There total 12 articles about N-(2-fluoro-4-{5-[2-(methoxymethyl)-2’-methylbiphenyl-4-yl]-1,2,4-oxadiazol-3-yl}benzoyl)-β-alanine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 1141472-89-0
methyl N-(2-fluoro-4-{5-[2-(methoxymethyl)-2'-methylbiphenyl-4-yl]-1,2,4-oxadiazol-3-yl}benzoyl)-beta-alaninate

: 1141472-91-4
N-(2-fluoro-4-{5-[2-(methoxymethyl)-2’-methylbiphenyl-4-yl]-1,2,4-oxadiazol-3-yl}benzoyl)-β-alanine

Guidance literature:: methyl N-(2-fluoro-4-{5-[2-(methoxymethyl)-2'-methylbiphenyl-4-yl]-1,2,4-oxadiazol-3-yl}benzoyl)-beta-alaninate; With sodium hydroxide; water; In methanol; at 20 ℃; for 1h;

With hydrogenchloride; In water; ethyl acetate;

Reference yield:

: 1141471-95-5
2-fluoro-4-{5-[2-(methoxymethyl)-2’-methylbiphenyl-4-yl]-1,2,4-oxadiazol-3-yl}benzoic acid

: 1141472-91-4
N-(2-fluoro-4-{5-[2-(methoxymethyl)-2’-methylbiphenyl-4-yl]-1,2,4-oxadiazol-3-yl}benzoyl)-β-alanine

Guidance literature:: Multi-step reaction with 3 steps

1: oxalyl dichloride / dichloromethane; N,N-dimethyl-formamide / 2 h / 20 °C

2: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 20 °C

3: sodium hydroxide / methanol; tetrahydrofuran / 1 h / 20 °C

With oxalyl dichloride; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1002/cmdc.201402557

Reference yield:

: 148547-19-7
4-Bromo-3-methylbenzoic acid methyl ester

: 1141472-91-4
N-(2-fluoro-4-{5-[2-(methoxymethyl)-2’-methylbiphenyl-4-yl]-1,2,4-oxadiazol-3-yl}benzoyl)-β-alanine

Guidance literature:: Multi-step reaction with 10 steps

1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / chloroform / 48 h / 70 °C / Inert atmosphere

2: 96 h / Reflux

3: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; toluene / 1 h / 110 °C / Inert atmosphere

4: sodium hydroxide / ethanol / 1 h / 60 °C

5: oxalyl dichloride / toluene; N,N-dimethyl-formamide / 3 h / 20 °C

6: pyridine / toluene / 36 h / 20 °C / Inert atmosphere; Reflux

7: sodium hydroxide / methanol; tetrahydrofuran / 12 h / 20 °C

8: oxalyl dichloride / dichloromethane; N,N-dimethyl-formamide / 2 h / 20 °C

9: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 20 °C

10: sodium hydroxide / methanol; tetrahydrofuran / 1 h / 20 °C

With pyridine; N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; oxalyl dichloride; 2,2'-azobis(isobutyronitrile); potassium carbonate; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In tetrahydrofuran; methanol; ethanol; dichloromethane; chloroform; water; N,N-dimethyl-formamide; toluene;
DOI:10.1002/cmdc.201402557