(4R)-3-(1-benzyl-3-methylpyrrolidin-3-yl) 5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate hydrochloride

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Chemical Name:(4R)-3-(1-benzyl-3-methylpyrrolidin-3-yl) 5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate hydrochloride
CAS No.:1404063-61-1
Molecular Formula:C₂₈H₃₁N₃O₆*ClH
Molecular Weight:542.032
Hs Code.:

Synonyms:(4R)-3-(1-benzyl-3-methylpyrrolidin-3-yl) 5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate hydrochloride

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Chemical Property of (4R)-3-(1-benzyl-3-methylpyrrolidin-3-yl) 5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate hydrochloride

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Technology Process of (4R)-3-(1-benzyl-3-methylpyrrolidin-3-yl) 5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate hydrochloride

There total 9 articles about (4R)-3-(1-benzyl-3-methylpyrrolidin-3-yl) 5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 27.8%

: 88712-56-5,106463-88-1,125185-92-4
methyl (R)-5-chlorocarbonyl-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3-carboxylate

: 96567-93-0
1-benzyl-3-methylpyrrolidin-3-ol

: 1404063-61-1
(4R)-3-(1-benzyl-3-methylpyrrolidin-3-yl) 5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate hydrochloride

Guidance literature:: methyl (R)-5-chlorocarbonyl-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3-carboxylate; 1-benzyl-3-methylpyrrolidin-3-ol; In dichloromethane; at -25 - 20 ℃; for 12h;

With hydrogenchloride;

Reference yield: 27.8%

: 88712-56-5,125185-92-4
1,4-dihydro-2,6-dimethyl-3-methoxycarbonyl-4-(3-nitrophenyl)-pyridine-5-carboxylic acid chloride

: 96567-93-0
1-benzyl-3-methylpyrrolidin-3-ol

: 1404063-61-1
(4R)-3-(1-benzyl-3-methylpyrrolidin-3-yl) 5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate hydrochloride

Guidance literature:: 1,4-dihydro-2,6-dimethyl-3-methoxycarbonyl-4-(3-nitrophenyl)-pyridine-5-carboxylic acid chloride; 1-benzyl-3-methylpyrrolidin-3-ol; In dichloromethane; at -25 - 20 ℃; for 12h;

With hydrogenchloride; In dichloromethane;

Reference yield:

: 99-61-6
3-nitro-benzaldehyde

: 1404063-61-1
(4R)-3-(1-benzyl-3-methylpyrrolidin-3-yl) 5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate hydrochloride

Guidance literature:: Multi-step reaction with 6 steps

1: ammonium bicarbonate / ethanol; water / 55 - 60 °C / Reflux

2: methanol; water; sodium hydroxide / 6 h / 70 °C

3: thionyl chloride / dichloromethane / -25 °C / Cooling with ice

4: cinchonidine / methanol / 3 h / 90 °C / Reflux

5: thionyl chloride / dichloromethane / -25 °C / Cooling with ice

6: dichloromethane / 12 h / -25 - 20 °C

With methanol; thionyl chloride; water; cinchonidine; ammonium bicarbonate; sodium hydroxide; In methanol; ethanol; dichloromethane; water;