(E)-methyl 2-(3-aminopropoxy)-4-[3-(3,5-di-tertbutylphenyl)-3-oxoprop-1-enyl]benzoate hydrochloride

Base Information

Chemical Name:(E)-methyl 2-(3-aminopropoxy)-4-[3-(3,5-di-tertbutylphenyl)-3-oxoprop-1-enyl]benzoate hydrochloride
CAS No.:1351169-37-3
Molecular Formula:C₂₈H₃₇NO₄*ClH
Molecular Weight:488.067
Hs Code.:

Synonyms:(E)-methyl 2-(3-aminopropoxy)-4-[3-(3,5-di-tertbutylphenyl)-3-oxoprop-1-enyl]benzoate hydrochloride

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Chemical Property of (E)-methyl 2-(3-aminopropoxy)-4-[3-(3,5-di-tertbutylphenyl)-3-oxoprop-1-enyl]benzoate hydrochloride

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Technology Process of (E)-methyl 2-(3-aminopropoxy)-4-[3-(3,5-di-tertbutylphenyl)-3-oxoprop-1-enyl]benzoate hydrochloride

There total 14 articles about (E)-methyl 2-(3-aminopropoxy)-4-[3-(3,5-di-tertbutylphenyl)-3-oxoprop-1-enyl]benzoate hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1351169-36-2
(E)-methyl 2-[3-(tert-butoxycarbonylamino)propoxy]-4-[3-(3,5-di-tert-butylphenyl)-3-oxoprop-1-enyl]benzoate

: 1351169-37-3
(E)-methyl 2-(3-aminopropoxy)-4-[3-(3,5-di-tertbutylphenyl)-3-oxoprop-1-enyl]benzoate hydrochloride

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; dichloromethane; at 20 ℃; Cooling with ice;
DOI:10.1016/j.bmc.2011.09.041

Reference yield:

: 717915-17-8
2,6-di-tert-butylbromoacetophenone

: 1351169-37-3
(E)-methyl 2-(3-aminopropoxy)-4-[3-(3,5-di-tertbutylphenyl)-3-oxoprop-1-enyl]benzoate hydrochloride

Guidance literature:: Multi-step reaction with 6 steps

1.1: acetonitrile / 8 h / Reflux

2.1: sodium methylate / methanol / Cooling with ice

2.2: 36 h / 20 °C

3.1: boron tribromide / dichloromethane / 0 °C

4.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / toluene / 0.5 h / Reflux

5.1: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 5 h / 90 °C

6.1: hydrogenchloride / 1,4-dioxane; dichloromethane / 20 °C / Cooling with ice

With hydrogenchloride; sodium methylate; boron tribromide; potassium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; potassium iodide; In 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide; toluene; acetonitrile; 1.1: Arbuzov reaction / 2.2: Horner-Wadsworth-Emmons reaction;
DOI:10.1016/j.bmc.2011.09.041

Reference yield:

: 1351169-33-9
C₂₆H₃₂O₄

: 1351169-37-3
(E)-methyl 2-(3-aminopropoxy)-4-[3-(3,5-di-tertbutylphenyl)-3-oxoprop-1-enyl]benzoate hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1: boron tribromide / dichloromethane / 0 °C

2: 1,8-diazabicyclo[5.4.0]undec-7-ene / toluene / 0.5 h / Reflux

3: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 5 h / 90 °C

4: hydrogenchloride / 1,4-dioxane; dichloromethane / 20 °C / Cooling with ice

With hydrogenchloride; boron tribromide; potassium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; potassium iodide; In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1016/j.bmc.2011.09.041