2-Piperidinobenzylamine

Base Information

• Chemical Name: 2-Piperidinobenzylamine
• CAS No.: 72752-54-6
• Molecular Formula: C12H18 N2
• Molecular Weight: 190.288
• Hs Code.: 2933399090
• European Community (EC) Number: 837-375-2
• DSSTox Substance ID: DTXSID90380141
• Nikkaji Number: J1.504.529I
• Wikidata: Q82170222
• Mol file: 72752-54-6.mol

Synonyms:2-PIPERIDINOBENZYLAMINE;72752-54-6;(2-(Piperidin-1-yl)phenyl)methanamine;(2-piperidin-1-ylphenyl)methanamine;[2-(Piperidin-1-Yl)Phenyl]Methanamine;[2-(1-Piperidinyl)phenyl]methanamine;Benzenemethanamine, 2-(1-piperidinyl)-;MFCD02682071;1-[2-(piperidin-1-yl)phenyl]methanamine;2-piperdinobenzylamine;Benzenemethanamine,2-(1-piperidinyl)-;SDCCGMLS-0066022.P001;2-Piperidin-1-ylbenzylamine;2-Piperidinobenzenemethanamine;2-piperidin-1-yl-benzylamine;SCHEMBL110730;(2-piperidin-1-ylbenzyl)amine;2-(Piperidin-1-yl)benzylamine;DTXSID90380141;VNNYEXSABSADDW-UHFFFAOYSA-N;2-piperidinobenzylamine, AldrichCPR;AMY20204;XCA75254;BBL040103;STK349854;AKOS000260760;SB41320;AS-31273;SY005813;CS-0206729;FT-0613365;EN300-127479;A866209;J-510284;Z335292556

Chemical Property of 2-Piperidinobenzylamine

Chemical Property:

• Vapor Pressure: 0.000177mmHg at 25°C
• Boiling Point: 329.5°C at 760 mmHg
• Flash Point: 135.8°C
• PSA: 29.26000
• Density: 1.047g/cm³
• LogP: 2.90090
• Storage Temp.: Store under an inert atmosphere
• XLogP3: 1.7
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 190.146998583
• Heavy Atom Count: 14
• Complexity: 164

Purity/Quality:

97% ^*data from raw suppliers

2-Piperidin-1-ylbenzylamine ^*data from reagent suppliers

Safty Information:

• Hazard Codes: C
• Statements: 36/37/38
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CCN(CC1)C2=CC=CC=C2CN

Technology Process of 2-Piperidinobenzylamine

There total 5 articles about 2-Piperidinobenzylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-(piperidin-1-yl)benzonitrile (72752-52-4) → (2-(piperidin-1-yl)phenyl)methanamine (72752-54-6)

Guidance literature:

With ammonia; hydrogen; nickel; In methanol; at 50 ℃; for 4h; under 3750.3 Torr;

DOI:10.1021/jm9810349

Reference yield: 94.0%

piperidine (110-89-4) + 2-fluorobenzonitrile (394-47-8) → (2-(piperidin-1-yl)phenyl)methanamine (72752-54-6)

Guidance literature:

piperidine; With dimethylsulfide borane complex; In tetrahydrofuran; at 0 ℃;

With n-butyllithium; In tetrahydrofuran; hexane; at 0 ℃;

2-fluorobenzonitrile; In tetrahydrofuran; hexane; at 65 ℃; for 2h; Further stages.;

DOI:10.1021/jo001388j

Reference yield:

piperidine (110-89-4) → (2-(piperidin-1-yl)phenyl)methanamine (72752-54-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 84 percent / N-formyl-piperidine / 64 h / 160 - 170 °C

2: 100 percent / H₂, NH₃ / Raney-Ni / methanol / 4 h / 50 °C / 3750.3 Torr

With N-Formylpiperidine; ammonia; hydrogen; nickel; In methanol;

DOI:10.1021/jm9810349

upstream raw materials:

2-(piperidin-1-yl)benzonitrile

piperidine

2-fluorobenzonitrile

2-Chlorobenzonitrile

Downstream raw materials:

2-(2-bromo-5-methoxyphenyl)-N-(2-piperidinobenzyl)acetamide

1-(2-piperidino-phenyl)-4-pentenylamine

3-methyl-1-(2-piperidino-phenyl)-3-butenylamine

2-cyclopropyl-1-(2-piperidino-phenyl)ethylamine