(S)-((2-(2-bromoethyl)-2-methylbut-3-en-1-yl)oxy)(tert-butyl)diphenylsilane

Base Information

Chemical Name:(S)-((2-(2-bromoethyl)-2-methylbut-3-en-1-yl)oxy)(tert-butyl)diphenylsilane
CAS No.:1492057-02-9
Molecular Formula:C₂₃H₃₁BrOSi
Molecular Weight:431.488
Hs Code.:

Synonyms:(S)-((2-(2-bromoethyl)-2-methylbut-3-en-1-yl)oxy)(tert-butyl)diphenylsilane

Suppliers and Price of (S)-((2-(2-bromoethyl)-2-methylbut-3-en-1-yl)oxy)(tert-butyl)diphenylsilane

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of (S)-((2-(2-bromoethyl)-2-methylbut-3-en-1-yl)oxy)(tert-butyl)diphenylsilane

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (S)-((2-(2-bromoethyl)-2-methylbut-3-en-1-yl)oxy)(tert-butyl)diphenylsilane

There total 10 articles about (S)-((2-(2-bromoethyl)-2-methylbut-3-en-1-yl)oxy)(tert-butyl)diphenylsilane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 1492057-01-8
(S)-3-(((tert-butyldiphenylsilyl)oxy)methyl)-3-methylpent-4-en-1-ol

: 1492057-02-9
(S)-((2-(2-bromoethyl)-2-methylbut-3-en-1-yl)oxy)(tert-butyl)diphenylsilane

Guidance literature:: With carbon tetrabromide; triphenylphosphine; In dichloromethane; at 20 ℃; for 0.5h; Inert atmosphere;
DOI:10.1016/j.tet.2013.10.064

Reference yield:

: 35660-94-7
(E)-2-methylbut-2-enoyl chloride

: 1492057-02-9
(S)-((2-(2-bromoethyl)-2-methylbut-3-en-1-yl)oxy)(tert-butyl)diphenylsilane

Guidance literature:: Multi-step reaction with 6 steps

1.1: n-butyllithium / hexane; tetrahydrofuran / 0.25 h / -78 °C

1.2: 0.75 h / -78 - 0 °C

2.1: sodium hexamethyldisilazane / tetrahydrofuran / -78 °C

2.2: 6 h / -50 °C

3.1: lithium borohydride / tetrahydrofuran / 0 °C

4.1: 1H-imidazole / dichloromethane / 20 °C

5.1: diisobutylaluminium hydride / dichloromethane; toluene / 3 h / -40 °C

6.1: triphenylphosphine; carbon tetrabromide / dichloromethane / 0.5 h / 20 °C / Inert atmosphere

With 1H-imidazole; lithium borohydride; n-butyllithium; carbon tetrabromide; sodium hexamethyldisilazane; diisobutylaluminium hydride; triphenylphosphine; In tetrahydrofuran; hexane; dichloromethane; toluene;
DOI:10.1016/j.tet.2013.10.064

Reference yield:

: 1492056-85-5
(S)-tert-butyl 3-((R)-4-isopropyl-2-oxooxazolidine-3-carbonyl)-3-methylpent-4-enoate

: 1492057-02-9
(S)-((2-(2-bromoethyl)-2-methylbut-3-en-1-yl)oxy)(tert-butyl)diphenylsilane

Guidance literature:: Multi-step reaction with 4 steps

1: lithium borohydride / tetrahydrofuran / 0 °C

2: 1H-imidazole / dichloromethane / 20 °C

3: diisobutylaluminium hydride / dichloromethane; toluene / 3 h / -40 °C

4: triphenylphosphine; carbon tetrabromide / dichloromethane / 0.5 h / 20 °C / Inert atmosphere

With 1H-imidazole; lithium borohydride; carbon tetrabromide; diisobutylaluminium hydride; triphenylphosphine; In tetrahydrofuran; dichloromethane; toluene;
DOI:10.1016/j.tet.2013.10.064