2(R)-3-[3-fluoro-4-(1,4-thiazepanyl)-phenylamino]-2-hydroxypropionic acid methyl ester

Base Information

• Chemical Name: 2(R)-3-[3-fluoro-4-(1,4-thiazepanyl)-phenylamino]-2-hydroxypropionic acid methyl ester
• CAS No.: 888958-16-5
• Molecular Formula: C₁₅H₂₁FN₂O₃S
• Molecular Weight: 328.408
• Mol file: 888958-16-5.mol

Synonyms:2(R)-3-[3-fluoro-4-(1,4-thiazepanyl)-phenylamino]-2-hydroxypropionic acid methyl ester

Chemical Property of 2(R)-3-[3-fluoro-4-(1,4-thiazepanyl)-phenylamino]-2-hydroxypropionic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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Technology Process of 2(R)-3-[3-fluoro-4-(1,4-thiazepanyl)-phenylamino]-2-hydroxypropionic acid methyl ester

There total 1 articles about 2(R)-3-[3-fluoro-4-(1,4-thiazepanyl)-phenylamino]-2-hydroxypropionic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-fluoro-4-(1,4-thiazepan-4-yl)benzenamine (273377-07-4) + methyl (2R)-glycidate (4538-50-5,85485-00-3,118712-39-3,111058-32-3) → 2(R)-3-[3-fluoro-4-(1,4-thiazepanyl)-phenylamino]-2-hydroxypropionic acid methyl ester (888958-16-5)

Guidance literature:

3-fluoro-4-(1,4-thiazepan-4-yl)benzenamine; methyl (2R)-glycidate; With lithium trifluoromethanesulfonate; In acetonitrile; for 47h; Heating / reflux;

With water; In acetonitrile; at 20 ℃;

Reference yield:

2(R)-3-[3-fluoro-4-(1,4-thiazepanyl)-phenylamino]-2-hydroxypropionic acid methyl ester (888958-16-5) + 1,1'-carbonyldiimidazole (530-62-1) → 5-(R)-3-[3-fluoro-4-(1,4-thiazepanyl)-phenyl]-2-oxo-oxazolidine-5-carboxylic acid methyl ester (888958-15-4)

Guidance literature:

In acetonitrile; at 23 - 50 ℃; for 0.25h;

upstream raw materials:

3-fluoro-4-(1,4-thiazepan-4-yl)benzenamine

methyl (2R)-glycidate

Downstream raw materials:

5-(R)-3-[3-fluoro-4-(1,4-thiazepanyl)-phenyl]-2-oxo-oxazolidine-5-carboxylic acid methyl ester