erythro-1-<2-(3,4,5-trimethoxyphenyl)-2-hydroxy-1-methylethyl>-4-(1,3-dihydro-2-oxo-2H-benzimidazol-1-yl)piperidine

Base Information

• Chemical Name: erythro-1-<2-(3,4,5-trimethoxyphenyl)-2-hydroxy-1-methylethyl>-4-(1,3-dihydro-2-oxo-2H-benzimidazol-1-yl)piperidine
• CAS No.: 83665-44-5
• Molecular Formula: C₂₄H₃₁N₃O₅
• Molecular Weight: 441.527

Synonyms:erythro-1-<2-(3,4,5-trimethoxyphenyl)-2-hydroxy-1-methylethyl>-4-(1,3-dihydro-2-oxo-2H-benzimidazol-1-yl)piperidine

Chemical Property of erythro-1-<2-(3,4,5-trimethoxyphenyl)-2-hydroxy-1-methylethyl>-4-(1,3-dihydro-2-oxo-2H-benzimidazol-1-yl)piperidine

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Technology Process of erythro-1-<2-(3,4,5-trimethoxyphenyl)-2-hydroxy-1-methylethyl>-4-(1,3-dihydro-2-oxo-2H-benzimidazol-1-yl)piperidine

There total 6 articles about erythro-1-<2-(3,4,5-trimethoxyphenyl)-2-hydroxy-1-methylethyl>-4-(1,3-dihydro-2-oxo-2H-benzimidazol-1-yl)piperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.1%

1-<2-oxo-2-(3,4,5-trimethoxyphenyl)-1-methylethyl>-4-(1,3-dihydro-2H-benzimidazol-2-one-1-yl)piperidine (74179-07-0) → 1-{1-[2-Hydroxy-1-methyl-2-(3,4,5-trimethoxy-phenyl)-ethyl]-piperidin-4-yl}-1,3-dihydro-benzoimidazol-2-one (74179-08-1,82454-29-3,82832-86-8,83259-47-6,83259-48-7,83259-49-8,83665-44-5,83708-93-4,83708-94-5)

Guidance literature:

With hydrogen; platinum(IV) oxide; In methanol; acetic acid; for 3h; Ambient temperature;

DOI:10.1248/cpb.30.462

Reference yield: 77.1%

1-<2-oxo-2-(3,4,5-trimethoxyphenyl)-1-methylethyl>-4-(1,3-dihydro-2H-benzimidazol-2-one-1-yl)piperidine (74179-07-0) → threo-1-<2-hydroxy-2-(3,4,5-trimethoxyphenyl)-1-methylethyl>-4-(1,3-dihydro-2H-benzimidazol-2-one-1-yl)piperidine (74179-08-1,82454-29-3,82832-86-8,83259-47-6,83259-48-7,83259-49-8,83665-44-5,83708-93-4,83708-94-5)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 - 5 ℃;

DOI:10.1248/cpb.30.462

Reference yield:

2-bromo-1-(3,4,5-trimethoxyphenyl)propan-1-one (52190-29-1) → 1-{1-[2-Hydroxy-1-methyl-2-(3,4,5-trimethoxy-phenyl)-ethyl]-piperidin-4-yl}-1,3-dihydro-benzoimidazol-2-one (74179-08-1,82454-29-3,82832-86-8,83259-47-6,83259-48-7,83259-49-8,83665-44-5,83708-93-4,83708-94-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 69.4 percent / Et₃N / methanol / Ambient temperature

2: 77.1 percent / H₂ / PtO₂ / aq. acetic acid; methanol / 3 h / Ambient temperature

With hydrogen; triethylamine; platinum(IV) oxide; In methanol; acetic acid;

DOI:10.1248/cpb.30.462

upstream raw materials:

1-<2-oxo-2-(3,4,5-trimethoxyphenyl)-1-methylethyl>-4-(1,3-dihydro-2H-benzimidazol-2-one-1-yl)piperidine

2-bromo-1-(3,4,5-trimethoxyphenyl)propan-1-one

4-(2-keto-1-benzimidazolinyl)piperidine

Downstream raw materials:

erythro-1-<2-(3,4,5-trimethoxyphenyl)-2-hydroxy-1-methylethyl>-4-(3-acetyl-2-oxo-1,3-dihydro-2H-benzimidazol-1-yl)piperidine

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