methyl 2-bromo-3-[3-fluoro-4-(5-methyl-2-phenyl-4-oxazolylmethoxy)phenyl]propionate

Base Information

Chemical Name:methyl 2-bromo-3-[3-fluoro-4-(5-methyl-2-phenyl-4-oxazolylmethoxy)phenyl]propionate
CAS No.:178239-22-0
Molecular Formula:C₂₁H₁₉BrFNO₄
Molecular Weight:448.289
Hs Code.:

Synonyms:methyl 2-bromo-3-[3-fluoro-4-(5-methyl-2-phenyl-4-oxazolylmethoxy)phenyl]propionate

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Chemical Property of methyl 2-bromo-3-[3-fluoro-4-(5-methyl-2-phenyl-4-oxazolylmethoxy)phenyl]propionate

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Technology Process of methyl 2-bromo-3-[3-fluoro-4-(5-methyl-2-phenyl-4-oxazolylmethoxy)phenyl]propionate

There total 2 articles about methyl 2-bromo-3-[3-fluoro-4-(5-methyl-2-phenyl-4-oxazolylmethoxy)phenyl]propionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 292638-85-8,9003-21-8,96-33-3
acrylic acid methyl ester

: 178610-64-5
3-fluoro-4-(5-methyl-2-phenyl-4-oxazolylmethoxy)aniline

: 178239-22-0
methyl 2-bromo-3-[3-fluoro-4-(5-methyl-2-phenyl-4-oxazolylmethoxy)phenyl]propionate

Guidance literature:: 3-fluoro-4-(5-methyl-2-phenyl-4-oxazolylmethoxy)aniline; With hydrogen bromide; sodium nitrite; In methanol; acetone; at 5 ℃; for 0.25h;

acrylic acid methyl ester; With copper(I) oxide; In methanol; acetone;
DOI:10.1248/cpb.50.100

Reference yield:

: 369-34-6
3,4-difluoronitrobenzene

: 178239-22-0
methyl 2-bromo-3-[3-fluoro-4-(5-methyl-2-phenyl-4-oxazolylmethoxy)phenyl]propionate

Guidance literature:: Multi-step reaction with 3 steps

1.1: 81 percent / NaH / dimethylformamide / 3 h / 20 °C

2.1: 100 percent / H₂ / 5 percent Pd/C / tetrahydrofuran / 760 Torr

3.1: aq. NaNO₂; HBr / methanol; acetone / 0.25 h / 5 °C

3.2: 75 percent / Cu₂O / methanol; acetone

With hydrogen bromide; hydrogen; sodium hydride; sodium nitrite; palladium on activated charcoal; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; acetone;
DOI:10.1248/cpb.50.100