5-amino-1-(3-methylsulfanyl-phenyl)-1H-pyrazole-4-carboxylic acid ethyl ester

Base Information

Chemical Name:5-amino-1-(3-methylsulfanyl-phenyl)-1H-pyrazole-4-carboxylic acid ethyl ester
CAS No.:954146-94-2
Molecular Formula:C₁₃H₁₅N₃O₂S
Molecular Weight:277.347
Hs Code.:

Synonyms:5-amino-1-(3-methylsulfanyl-phenyl)-1H-pyrazole-4-carboxylic acid ethyl ester

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Chemical Property of 5-amino-1-(3-methylsulfanyl-phenyl)-1H-pyrazole-4-carboxylic acid ethyl ester

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Technology Process of 5-amino-1-(3-methylsulfanyl-phenyl)-1H-pyrazole-4-carboxylic acid ethyl ester

There total 1 articles about 5-amino-1-(3-methylsulfanyl-phenyl)-1H-pyrazole-4-carboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 42466-67-1,42466-69-3
ethyl (ethoxymethylene)cyanoacetate

: 954146-94-2
5-amino-1-(3-methylsulfanyl-phenyl)-1H-pyrazole-4-carboxylic acid ethyl ester

Guidance literature:: (3-methylsulfanyl-phenyl)-hydrazine hydrochloride; With sodium hydroxide; In ethanol; for 0.5h;

ethyl (ethoxymethylene)cyanoacetate; In ethanol; at 80 ℃; for 2h;

Reference yield:

: 1056937-39-3
4-bromo-N-(4-chloro-phenyl)-benzimidoylchloride

: 954146-94-2
5-amino-1-(3-methylsulfanyl-phenyl)-1H-pyrazole-4-carboxylic acid ethyl ester

: 954146-93-1
6-(4-bromo-phenyl)-5-(4-chloro-phenyl)-1-(3-methylsulfanyl-phenyl)-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one

Guidance literature:: at 170 ℃; for 6h; Heating / reflux;

Reference yield:

: 954146-94-2
5-amino-1-(3-methylsulfanyl-phenyl)-1H-pyrazole-4-carboxylic acid ethyl ester

: 3-[6-[4-(5-amino-pyridin-2-yl)-phenyl]-5-(4-chloro-phenyl)-4-oxo-4,5-dihydro-pyrazolo[3,4-d]pyrimidin-1-yl]-benzenesulfonamide

Guidance literature:: Multi-step reaction with 11 steps

1: 6 h / 170 °C / Heating / reflux

2: Monoperoxyphthalic acid, magnesium salt / methanol; dichloromethane / 1 h / 0 °C

3: sodium acetate / 5 h / Heating / reflux

4: Monoperoxyphthalic acid, magnesium salt / methanol; dichloromethane / 2 h / 0 - 20 °C

5: methanol; sodium hydroxide; water / tetrahydrofuran / 1.5 h / 0 °C

6: sulfuryl dichloride / dichloromethane / 1.5 h / 0 °C

7: ammonia / tetrahydrofuran; water / 0.75 h / 0 °C

8: toluene-4-sulfonic acid / toluene / 18 h / Heating / reflux

9: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / N,N-dimethyl-formamide / 2 h / 80 °C

10: caesium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / N,N-dimethyl-formamide / 6 h / 100 °C

11: water; trifluoroacetic acid / 3 h / Heating / reflux

With methanol; sodium hydroxide; sulfuryl dichloride; ammonia; water; potassium acetate; sodium acetate; caesium carbonate; toluene-4-sulfonic acid; Monoperoxyphthalic acid, magnesium salt; trifluoroacetic acid; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; toluene; 10: Suzuki Coupling;