Technology Process of diazo-acetic acid 2-(5-methyl-benzofuran-3-yl)-phenyl ester
There total 10 articles about diazo-acetic acid 2-(5-methyl-benzofuran-3-yl)-phenyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
sodium hydride;
In
tetrahydrofuran;
at 0 - 20 ℃;
DOI:10.1021/ol006578v
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: 36.2 g / K2CO3 / acetone / 12 h / Heating
2.1: 78 percent / N,N-dimethylaniline / 16 h / Heating
3.1: O3 / methanol / 0.75 h / -78 °C
3.2: 66 percent / DMS / methanol / 12 h / 20 °C
4.1: 90 percent / p-TsOH / benzene / 3 h / Heating
5.1: 95 percent / HCO2NH4 / Pd/C / methanol / 0.25 h / Heating
6.1: 81 percent / NaH / tetrahydrofuran / 0 - 20 °C
With
ammonium formate; sodium hydride; potassium carbonate; toluene-4-sulfonic acid; ozone; N,N-dimethyl-aniline;
palladium on activated charcoal;
In
tetrahydrofuran; methanol; acetone; benzene;
2.1: Claisen rearrangement;
DOI:10.1021/ol006578v
- Guidance literature:
-
Multi-step reaction with 9 steps
1.1: K2CO3 / acetone / 12 h / Heating
2.1: 34.0 g / DIBAL / tetrahydrofuran / 0.5 h / -78 °C
3.1: PBr3; pyridine / diethyl ether / 2 h / -15 °C
4.1: 36.2 g / K2CO3 / acetone / 12 h / Heating
5.1: 78 percent / N,N-dimethylaniline / 16 h / Heating
6.1: O3 / methanol / 0.75 h / -78 °C
6.2: 66 percent / DMS / methanol / 12 h / 20 °C
7.1: 90 percent / p-TsOH / benzene / 3 h / Heating
8.1: 95 percent / HCO2NH4 / Pd/C / methanol / 0.25 h / Heating
9.1: 81 percent / NaH / tetrahydrofuran / 0 - 20 °C
With
pyridine; ammonium formate; phosphorus tribromide; sodium hydride; diisobutylaluminium hydride; potassium carbonate; toluene-4-sulfonic acid; ozone; N,N-dimethyl-aniline;
palladium on activated charcoal;
In
tetrahydrofuran; methanol; diethyl ether; acetone; benzene;
5.1: Claisen rearrangement;
DOI:10.1021/ol006578v
