(4-{[(S)-2-amino-3-(3,4-difluoro-phenyl)-propionylamino]-methyl}-benzyl)-carbamic acid 9H-fluoren-9-ylmethyl ester hydrochloride

Base Information

Chemical Name:(4-{[(S)-2-amino-3-(3,4-difluoro-phenyl)-propionylamino]-methyl}-benzyl)-carbamic acid 9H-fluoren-9-ylmethyl ester hydrochloride
CAS No.:1417694-27-9
Molecular Formula:C₃₂H₂₉F₂N₃O₃*ClH
Molecular Weight:578.058
Hs Code.:

Synonyms:(4-{[(S)-2-amino-3-(3,4-difluoro-phenyl)-propionylamino]-methyl}-benzyl)-carbamic acid 9H-fluoren-9-ylmethyl ester hydrochloride

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Chemical Property of (4-{[(S)-2-amino-3-(3,4-difluoro-phenyl)-propionylamino]-methyl}-benzyl)-carbamic acid 9H-fluoren-9-ylmethyl ester hydrochloride

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Technology Process of (4-{[(S)-2-amino-3-(3,4-difluoro-phenyl)-propionylamino]-methyl}-benzyl)-carbamic acid 9H-fluoren-9-ylmethyl ester hydrochloride

There total 5 articles about (4-{[(S)-2-amino-3-(3,4-difluoro-phenyl)-propionylamino]-methyl}-benzyl)-carbamic acid 9H-fluoren-9-ylmethyl ester hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1417694-26-8
((S)-2-(3,4-difluoro-phenyl)-1-{4-[(9H-fluoren-9-ylmethoxycarbonylamino)-methyl]-benzylcarbamoyl}-ethyl)-carbamic acid tert-butyl ester

: 1417694-27-9
(4-{[(S)-2-amino-3-(3,4-difluoro-phenyl)-propionylamino]-methyl}-benzyl)-carbamic acid 9H-fluoren-9-ylmethyl ester hydrochloride

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 1h;

Reference yield:

: 1417694-24-6
[4-(tert-butoxycarbonylamino-methyl)-benzyl]-carbamic acid 9H-fluoren-9-ylmethyl ester

: 1417694-27-9
(4-{[(S)-2-amino-3-(3,4-difluoro-phenyl)-propionylamino]-methyl}-benzyl)-carbamic acid 9H-fluoren-9-ylmethyl ester hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C

2: benzotriazol-1-ol; triethylamine; 1,1'-carbonyldiimidazole / dichloromethane; N,N-dimethyl-formamide / 18 h / 0 - 20 °C

3: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C

With hydrogenchloride; benzotriazol-1-ol; triethylamine; 1,1'-carbonyldiimidazole; In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1417694-25-7
(4-aminomethyl-benzyl)-carbamic acid 9H-fluoren-9-ylmethyl ester hydrochloride

: 1417694-27-9
(4-{[(S)-2-amino-3-(3,4-difluoro-phenyl)-propionylamino]-methyl}-benzyl)-carbamic acid 9H-fluoren-9-ylmethyl ester hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: benzotriazol-1-ol; triethylamine; 1,1'-carbonyldiimidazole / dichloromethane; N,N-dimethyl-formamide / 18 h / 0 - 20 °C

2: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C

With hydrogenchloride; benzotriazol-1-ol; triethylamine; 1,1'-carbonyldiimidazole; In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;