all-trans-1,3-diphenyl-2,4-bis-[α-acetoxybenzyl]cyclobutane

Base Information

• Chemical Name: all-trans-1,3-diphenyl-2,4-bis-[α-acetoxybenzyl]cyclobutane
• CAS No.: 19805-00-6
• Molecular Formula: C₃₄H₃₂O₄
• Molecular Weight: 504.626
• Mol file: 19805-00-6.mol

Synonyms:all-trans-1,3-diphenyl-2,4-bis-[α-acetoxybenzyl]cyclobutane

Chemical Property of all-trans-1,3-diphenyl-2,4-bis-[α-acetoxybenzyl]cyclobutane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of all-trans-1,3-diphenyl-2,4-bis-[α-acetoxybenzyl]cyclobutane

There total 2 articles about all-trans-1,3-diphenyl-2,4-bis-[α-acetoxybenzyl]cyclobutane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

1,3-diphenyl-3-hydroxypropene (4663-33-6,62668-02-4,62839-70-7,116127-91-4,132014-29-0,136981-81-2,148616-45-9) + acetic anhydride (108-24-7) → cis,trans,trans-1,3-diphenyl-2,4-bis-[α-acetoxybenzyl]cyclobutane + all-trans-1,3-diphenyl-2,4-bis-[α-acetoxybenzyl]cyclobutane (19805-00-6)

Guidance literature:

With boron trifluoride diethyl etherate;

DOI:10.1016/j.tet.2009.01.016

Reference yield:

(E)-1,3-diphenyl-2-propen-1-ol (62668-02-4) → all-trans-1,3-diphenyl-2,4-bis-[α-acetoxybenzyl]cyclobutane (19805-00-6)

Guidance literature:

Multi-step reaction with 2 steps

1: HBr, FeCl₃ / acetic acid

2: KOAc

With hydrogen bromide; potassium acetate; iron(III) chloride; In acetic acid;

Reference yield:

all-trans-1,3-diphenyl-2,4-bis-[α-acetoxybenzyl]cyclobutane (19805-00-6) → (2,4-diphenylcyclobutane-1,3-diyl)bis(phenylmethanol)

Guidance literature:

With lithium hydroxide; water; In methanol; for 3h; Reflux;

DOI:10.1016/j.tet.2009.01.016

upstream raw materials:

(E)-1,3-diphenyl-2-propen-1-ol

1,3-diphenyl-3-hydroxypropene

acetic anhydride