(R)-2-phenyl-1-(1-(2-(2,3,4-trimethoxybenzamido)ethyl)-1H-1,2,3-triazole-4-carboxamido)ethylboronic acid

Base Information

Chemical Name:(R)-2-phenyl-1-(1-(2-(2,3,4-trimethoxybenzamido)ethyl)-1H-1,2,3-triazole-4-carboxamido)ethylboronic acid
CAS No.:1613134-35-2
Molecular Formula:C₂₃H₂₈BN₅O₇
Molecular Weight:497.316
Hs Code.:

Synonyms:(R)-2-phenyl-1-(1-(2-(2,3,4-trimethoxybenzamido)ethyl)-1H-1,2,3-triazole-4-carboxamido)ethylboronic acid

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Chemical Property of (R)-2-phenyl-1-(1-(2-(2,3,4-trimethoxybenzamido)ethyl)-1H-1,2,3-triazole-4-carboxamido)ethylboronic acid

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Technology Process of (R)-2-phenyl-1-(1-(2-(2,3,4-trimethoxybenzamido)ethyl)-1H-1,2,3-triazole-4-carboxamido)ethylboronic acid

There total 3 articles about (R)-2-phenyl-1-(1-(2-(2,3,4-trimethoxybenzamido)ethyl)-1H-1,2,3-triazole-4-carboxamido)ethylboronic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 20.0%

: 1613134-43-2
1-[2-(2,3,4-trimethoxybenzoylamino)ethyl]-1H-[1,2,3]triazole-4-carboxylic acid [(R)-2-phenyl-1-((1S,2S,6R,8S)-2,9,9-trimethyl-3,5-dioxa-4-boratricyclo[6.1.1.0^2,6]dec-4-yl)ethyl]amide

: 1613134-35-2
(R)-2-phenyl-1-(1-(2-(2,3,4-trimethoxybenzamido)ethyl)-1H-1,2,3-triazole-4-carboxamido)ethylboronic acid

Guidance literature:: With hydrogenchloride; Dihydroxy-isobutyl-boran; In methanol; hexane; water; at 20 ℃;

Reference yield:

: 573-11-5
2,3,4-Trimethoxy-benzoic acid

: 1613134-35-2
(R)-2-phenyl-1-(1-(2-(2,3,4-trimethoxybenzamido)ethyl)-1H-1,2,3-triazole-4-carboxamido)ethylboronic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl acetamide / 1 h / 0 °C

1.2: 20 °C

2.1: sodium hydroxide / methanol / 20 °C

3.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0 - 20 °C

4.1: hydrogenchloride; Dihydroxy-isobutyl-boran / methanol; water; hexane / 20 °C

With hydrogenchloride; Dihydroxy-isobutyl-boran; N-ethyl-N,N-diisopropylamine; HATU; sodium hydroxide; In methanol; hexane; N,N-dimethyl acetamide; water; N,N-dimethyl-formamide;

Reference yield:

: 1613134-40-9
1-[2-(2,3,4-trimethoxy-benzoylamino)-ethyl]-1H-[1,2,3]triazole-4-carboxylic acid methyl ester

: 1613134-35-2
(R)-2-phenyl-1-(1-(2-(2,3,4-trimethoxybenzamido)ethyl)-1H-1,2,3-triazole-4-carboxamido)ethylboronic acid

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydroxide / methanol / 20 °C

2: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0 - 20 °C

3: hydrogenchloride; Dihydroxy-isobutyl-boran / methanol; water; hexane / 20 °C

With hydrogenchloride; Dihydroxy-isobutyl-boran; N-ethyl-N,N-diisopropylamine; HATU; sodium hydroxide; In methanol; hexane; water; N,N-dimethyl-formamide;