(2S,5S)-2-(3',4',5'-trimethoxyphenyl)-5-[3-methoxy-5-(2'-t-butyldimethylsilyloxyethanesulfanyl)-4-propoxyphenyl]-2,5-dihydrofuran

Base Information

Chemical Name:(2S,5S)-2-(3',4',5'-trimethoxyphenyl)-5-[3-methoxy-5-(2'-t-butyldimethylsilyloxyethanesulfanyl)-4-propoxyphenyl]-2,5-dihydrofuran
CAS No.:481725-19-3
Molecular Formula:C₃₁H₄₆O₇SSi
Molecular Weight:590.854
Hs Code.:

Synonyms:(2S,5S)-2-(3',4',5'-trimethoxyphenyl)-5-[3-methoxy-5-(2'-t-butyldimethylsilyloxyethanesulfanyl)-4-propoxyphenyl]-2,5-dihydrofuran

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Chemical Property of (2S,5S)-2-(3',4',5'-trimethoxyphenyl)-5-[3-methoxy-5-(2'-t-butyldimethylsilyloxyethanesulfanyl)-4-propoxyphenyl]-2,5-dihydrofuran

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Technology Process of (2S,5S)-2-(3',4',5'-trimethoxyphenyl)-5-[3-methoxy-5-(2'-t-butyldimethylsilyloxyethanesulfanyl)-4-propoxyphenyl]-2,5-dihydrofuran

There total 11 articles about (2S,5S)-2-(3',4',5'-trimethoxyphenyl)-5-[3-methoxy-5-(2'-t-butyldimethylsilyloxyethanesulfanyl)-4-propoxyphenyl]-2,5-dihydrofuran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 481725-18-2
(1R,2S,3S,5S,6R,7S)-4,10-dioxa-3-[3-methoxy-5-(2'-t-butyldimethylsilyloxyethanesulfanyl)-4-propoxy]-5-[(3',4',5')-trimethoxyphenyl]-tricyclo[5.2.1.0^2,6]dec-8-ene

: 481725-19-3
(2S,5S)-2-(3',4',5'-trimethoxyphenyl)-5-[3-methoxy-5-(2'-t-butyldimethylsilyloxyethanesulfanyl)-4-propoxyphenyl]-2,5-dihydrofuran

Guidance literature:: at 450 ℃; under 0.001 Torr;
DOI:10.1016/S0957-4166(02)00334-8

Reference yield:

: 5438-36-8
5-iodovaniline

: 481725-19-3
(2S,5S)-2-(3',4',5'-trimethoxyphenyl)-5-[3-methoxy-5-(2'-t-butyldimethylsilyloxyethanesulfanyl)-4-propoxyphenyl]-2,5-dihydrofuran

Guidance literature:: Multi-step reaction with 9 steps

1.1: 96 percent / cesium carbonate / dimethylformamide / 2 h / 50 °C

2.1: 91 percent / 2-methyl-2-butene; aq. sodium chlorite; NaH₂PO₄ / 2-methyl-propan-2-ol / 4 h / 20 °C

3.1: oxalyl chloride / dimethylformamide; CH₂Cl₂ / 18 h / 20 °C

4.1: 1.6 g / 2-mercaptopyridine oxide sodium salt; BrCCl₃; AIBN / 0.08 h / Heating

5.1: 77 percent / copper bronze / dimethylformamide / 20 h / 100 °C

6.1: 92 percent / imidazole / dimethylformamide / 20 °C

7.1: t-BuLi / pentane / 0.5 h / -78 °C

7.2: 53 percent / pentane; tetrahydrofuran / 0.5 h / -78 °C

8.1: 75 percent / NaBH₃CN; Cl₂CHCO₂H / various solvent(s) / 0.5 h / -25 °C

9.1: 67 percent / 450 °C / 0 Torr

With 1H-imidazole; dichloro-acetic acid; sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene; oxalyl dichloride; 2,2'-azobis(isobutyronitrile); Bromotrichloromethane; tert.-butyl lithium; 2-mercaptopyridine-1-oxide sodium salt; copper; sodium cyanoborohydride; caesium carbonate; In dichloromethane; N,N-dimethyl-formamide; tert-butyl alcohol; pentane;
DOI:10.1016/S0957-4166(02)00334-8

Reference yield:

: 106331-89-9
3-methoxy-4-n-propyloxy-5-iodobenzaldehyde

: 481725-19-3
(2S,5S)-2-(3',4',5'-trimethoxyphenyl)-5-[3-methoxy-5-(2'-t-butyldimethylsilyloxyethanesulfanyl)-4-propoxyphenyl]-2,5-dihydrofuran

Guidance literature:: Multi-step reaction with 8 steps

1.1: 91 percent / 2-methyl-2-butene; aq. sodium chlorite; NaH₂PO₄ / 2-methyl-propan-2-ol / 4 h / 20 °C

2.1: oxalyl chloride / dimethylformamide; CH₂Cl₂ / 18 h / 20 °C

3.1: 1.6 g / 2-mercaptopyridine oxide sodium salt; BrCCl₃; AIBN / 0.08 h / Heating

4.1: 77 percent / copper bronze / dimethylformamide / 20 h / 100 °C

5.1: 92 percent / imidazole / dimethylformamide / 20 °C

6.1: t-BuLi / pentane / 0.5 h / -78 °C

6.2: 53 percent / pentane; tetrahydrofuran / 0.5 h / -78 °C

7.1: 75 percent / NaBH₃CN; Cl₂CHCO₂H / various solvent(s) / 0.5 h / -25 °C

8.1: 67 percent / 450 °C / 0 Torr

With 1H-imidazole; dichloro-acetic acid; sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene; oxalyl dichloride; 2,2'-azobis(isobutyronitrile); Bromotrichloromethane; tert.-butyl lithium; 2-mercaptopyridine-1-oxide sodium salt; copper; sodium cyanoborohydride; In dichloromethane; N,N-dimethyl-formamide; tert-butyl alcohol; pentane;
DOI:10.1016/S0957-4166(02)00334-8