2-Benzyloxycarbonylamino-5-carbamoyl-2-trifluoromethyl-pentanoic acid ethyl ester

Base Information

Chemical Name:2-Benzyloxycarbonylamino-5-carbamoyl-2-trifluoromethyl-pentanoic acid ethyl ester
CAS No.:208929-80-0
Molecular Formula:C₁₇H₂₁F₃N₂O₅
Molecular Weight:390.359
Hs Code.:

Synonyms:2-Benzyloxycarbonylamino-5-carbamoyl-2-trifluoromethyl-pentanoic acid ethyl ester

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Chemical Property of 2-Benzyloxycarbonylamino-5-carbamoyl-2-trifluoromethyl-pentanoic acid ethyl ester

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Technology Process of 2-Benzyloxycarbonylamino-5-carbamoyl-2-trifluoromethyl-pentanoic acid ethyl ester

There total 1 articles about 2-Benzyloxycarbonylamino-5-carbamoyl-2-trifluoromethyl-pentanoic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2-Benzyloxycarbonylamino-2-trifluoromethyl-hexanedioic acid 1-ethyl ester

: 208929-80-0
2-Benzyloxycarbonylamino-5-carbamoyl-2-trifluoromethyl-pentanoic acid ethyl ester

Guidance literature:: With pyridine; ammonium hydroxide; 2,3,4,5,6-pentafluorophenol; dicyclohexyl-carbodiimide; Yield given. Multistep reaction; 1) CH₂Cl₂, room temperature, 2 h; -20 deg C, 1 h, 2), 2) dioxane, H₂O, 30 min;
DOI:10.1016/S0040-4020(98)00282-8

Reference yield: 81.8%

: 208929-80-0
2-Benzyloxycarbonylamino-5-carbamoyl-2-trifluoromethyl-pentanoic acid ethyl ester

: 208929-81-1
2-Benzyloxycarbonylamino-5-carbamoyl-2-trifluoromethyl-pentanoic acid

Guidance literature:: With potassium hydroxide; In methanol; water; Ambient temperature;
DOI:10.1016/S0040-4020(98)00282-8

Reference yield:

: 208929-80-0
2-Benzyloxycarbonylamino-5-carbamoyl-2-trifluoromethyl-pentanoic acid ethyl ester

: N-(1-Carbamoyl-2-phenyl-ethyl)-3-[2-(2,5-diamino-2-trifluoromethyl-pentanoylamino)-acetylamino]-succinamic acid

Guidance literature:: Multi-step reaction with 5 steps

1: 81.8 percent / KOH / methanol; H₂O / Ambient temperature

2: 78 percent / 1,1-bis(trifluoroacetoxy)iodobenzene, 0.1 N HCl / acetonitrile; H₂O / Ambient temperature

3: 81 percent / NaOH / dioxane; H₂O / 1.5 h / Ambient temperature

4: 1) DCC / 1) CH₂Cl₂, DMF, 2 h, 2) CH₂Cl₂, DMF, room temperature, 3 h

5: 1) 1,4-cyclohexadiene, 10percent Pd/C, 2) TFA / 1) MeOH, room temperature, 1 h, 2) room temperature, 1 h

With hydrogenchloride; potassium hydroxide; sodium hydroxide; palladium on activated charcoal; cyclohexa-1,4-diene; dicyclohexyl-carbodiimide; trifluoroacetic acid; bis-[(trifluoroacetoxy)iodo]benzene; In 1,4-dioxane; methanol; water; acetonitrile;
DOI:10.1016/S0040-4020(98)00282-8