1,3-O-benzylidene-2-C-methylthreitol

Base Information

• Chemical Name: 1,3-O-benzylidene-2-C-methylthreitol
• CAS No.: 1001850-37-8
• Molecular Formula: C₁₂H₁₆O₄
• Molecular Weight: 224.257
• Mol file: 1001850-37-8.mol

Synonyms:1,3-O-benzylidene-2-C-methylthreitol

Chemical Property of 1,3-O-benzylidene-2-C-methylthreitol

Chemical Property:

Purity/Quality:

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Technology Process of 1,3-O-benzylidene-2-C-methylthreitol

There total 1 articles about 1,3-O-benzylidene-2-C-methylthreitol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

(2S,4R,5R)-4-(t-butyldimethylsilyloxymethyl)-5,5-oxymethylene-2-phenyl-1,3-dioxane → 1,3-O-benzylidene-2-C-methylthreitol (1001850-37-8)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 ℃; for 1h;

DOI:10.1021/jo0711900

Reference yield: 80.0%

1,3-O-benzylidene-2-C-methylthreitol (1001850-37-8) + dibenzyl phosphochloridate (538-37-4) → 1,3-O-benzylidene-2-C-methylthreitol 4-dibenzylphosphate

Guidance literature:

With n-butyllithium; In tetrahydrofuran; hexane; benzene; at -75 - 25 ℃; for 0.416667h;

DOI:10.1021/jo0711900

Reference yield: 35.0%

1,3-O-benzylidene-2-C-methylthreitol (1001850-37-8) + Dibenzyl N,N-diisopropylphosphoramidite (108549-23-1) → 1,3-O-benzylidene-2-C-methyl-D-threitol 2,4-diphosphate tetrabenzyl ester + 1,3-O-benzylidene-2-C-methyl-D-threitol 2,4-cyclophosphate benzyl ester

Guidance literature:

1,3-O-benzylidene-2-C-methylthreitol; Dibenzyl N,N-diisopropylphosphoramidite; With 1H-tetrazole; In acetonitrile; at 20 ℃; for 5h;

With 3-chloro-benzenecarboperoxoic acid; In acetonitrile; at 0 - 20 ℃; for 1h; Further stages.;

DOI:10.1021/jo0711900