p-Nitrobenzyl (4RS,5RS,6RS)-4-benzoyloxy-3-ethylsulphinyl-6-methyl-7-oxo-1-azabicyclo<3.2.0>hept-2-ene-2-carboxylate

Base Information

Chemical Name:p-Nitrobenzyl (4RS,5RS,6RS)-4-benzoyloxy-3-ethylsulphinyl-6-methyl-7-oxo-1-azabicyclo<3.2.0>hept-2-ene-2-carboxylate
CAS No.:137440-00-7
Molecular Formula:C₂₄H₂₂N₂O₈S
Molecular Weight:498.513
Hs Code.:

Synonyms:p-Nitrobenzyl (4RS,5RS,6RS)-4-benzoyloxy-3-ethylsulphinyl-6-methyl-7-oxo-1-azabicyclo<3.2.0>hept-2-ene-2-carboxylate

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Chemical Property of p-Nitrobenzyl (4RS,5RS,6RS)-4-benzoyloxy-3-ethylsulphinyl-6-methyl-7-oxo-1-azabicyclo<3.2.0>hept-2-ene-2-carboxylate

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Technology Process of p-Nitrobenzyl (4RS,5RS,6RS)-4-benzoyloxy-3-ethylsulphinyl-6-methyl-7-oxo-1-azabicyclo<3.2.0>hept-2-ene-2-carboxylate

There total 5 articles about p-Nitrobenzyl (4RS,5RS,6RS)-4-benzoyloxy-3-ethylsulphinyl-6-methyl-7-oxo-1-azabicyclo<3.2.0>hept-2-ene-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 137439-99-7
p-Nitrobenzyl (4RS,5RS,6RS)-4-benzoyloxy-3-chloro-3-ethylsulphinyl-6-methyl-7-oxo-1-azabicyclo<3.2.0>heptane-2-carboxylate

: 137440-00-7
p-Nitrobenzyl (4RS,5RS,6RS)-4-benzoyloxy-3-ethylsulphinyl-6-methyl-7-oxo-1-azabicyclo<3.2.0>hept-2-ene-2-carboxylate

Guidance literature:: With 1,8-diazabicyclo[5.4.0]undec-7-ene; In ethyl acetate; for 2h;
DOI:10.1039/P19910002399

Reference yield:

: 112563-67-4
p-Nitrobenzyl (4RS,5SR,6SR)-4-benzoyloxy-7-oxo-6-(2-oxoethyl)-1-azabicyclo<3.2.0>hept-2-ene-2-carboxylate

: 137440-00-7
p-Nitrobenzyl (4RS,5RS,6RS)-4-benzoyloxy-3-ethylsulphinyl-6-methyl-7-oxo-1-azabicyclo<3.2.0>hept-2-ene-2-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: 66 percent / K₂CO₃ / dimethylformamide / 0.08 h

2: 82 percent / tris(triphenylphosphine)rhodium(I) chloride / CH₂Cl₂ / 16 h / Heating

3: 65 percent / iodobenzene dichloride, pyridine / CH₂Cl₂; H₂O / 0.5 h / 0 °C

4: 85 percent / DBU / ethyl acetate / 2 h

With pyridine; Wilkinson's catalyst; 1,2-Dichloro-3-iodobenzene; potassium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; In dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1039/P19910002399

Reference yield:

: 137439-98-6
p-Nitrobenzyl (2RS,3SR,4SR,5SR,6SR)-4-benzoyloxy-3-ethylthio-6-methyl-7-oxo-1-azabicyclo<3.2.0>heptane-2-carboxylate

: 137440-00-7
p-Nitrobenzyl (4RS,5RS,6RS)-4-benzoyloxy-3-ethylsulphinyl-6-methyl-7-oxo-1-azabicyclo<3.2.0>hept-2-ene-2-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 65 percent / iodobenzene dichloride, pyridine / CH₂Cl₂; H₂O / 0.5 h / 0 °C

2: 85 percent / DBU / ethyl acetate / 2 h

With pyridine; 1,2-Dichloro-3-iodobenzene; 1,8-diazabicyclo[5.4.0]undec-7-ene; In dichloromethane; water; ethyl acetate;
DOI:10.1039/P19910002399