[4-(4-chloro-5-trifluoromethyl-pyrimidin-2-ylamino)-phenyl]-(4-methyl-piperazin-1-yl)-methanone

Base Information

• Chemical Name: [4-(4-chloro-5-trifluoromethyl-pyrimidin-2-ylamino)-phenyl]-(4-methyl-piperazin-1-yl)-methanone
• CAS No.: 919116-56-6
• Molecular Formula: C₁₇H₁₇ClF₃N₅O
• Molecular Weight: 399.803

Synonyms:[4-(4-chloro-5-trifluoromethyl-pyrimidin-2-ylamino)-phenyl]-(4-methyl-piperazin-1-yl)-methanone

Chemical Property of [4-(4-chloro-5-trifluoromethyl-pyrimidin-2-ylamino)-phenyl]-(4-methyl-piperazin-1-yl)-methanone

Chemical Property:

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Technology Process of [4-(4-chloro-5-trifluoromethyl-pyrimidin-2-ylamino)-phenyl]-(4-methyl-piperazin-1-yl)-methanone

There total 1 articles about [4-(4-chloro-5-trifluoromethyl-pyrimidin-2-ylamino)-phenyl]-(4-methyl-piperazin-1-yl)-methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-methyl-piperazine (109-01-3) + 4-(4-chloro-5-trifluoromethyl-pyrimidin-2-ylamino)-benzoyl Chloride (1187851-75-7) → [4-(4-chloro-5-trifluoromethyl-pyrimidin-2-ylamino)-phenyl]-(4-methyl-piperazin-1-yl)-methanone (919116-56-6)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 20 ℃; for 16h;

Reference yield: 96.0%

[4-(4-chloro-5-trifluoromethyl-pyrimidin-2-ylamino)-phenyl]-(4-methyl-piperazin-1-yl)-methanone (919116-56-6) + (1RS,2SR)-cispentacin (57043-00-2,37910-65-9) → (+/-)-(1S*,2R*)-2-[2-[4-(4-methylpiperazin-1-carbonyl)phenylamino]-5-trifluoromethylpyrimidin-4-ylamino]cyclopentanecarboxylic acid

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In butan-1-ol; at 110 ℃; for 1h; Microwave irradiation;

Reference yield: 68.0%

[4-(4-chloro-5-trifluoromethyl-pyrimidin-2-ylamino)-phenyl]-(4-methyl-piperazin-1-yl)-methanone (919116-56-6) + benzyl cis-N-(2-aminocyclohexyl)carbamate (1353973-30-4,445479-92-5) → benzyl (+/-)-((1S*,2R*)-2-{2-[4-(4-methylpiperazin-1-carbonyl)phenylamino]-5-trifluoromethylpyrimidin-4-ylamino}cyclohexyl)carbamate

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In 1-methyl-pyrrolidin-2-one; at 70 ℃; for 48h;

upstream raw materials:

1-methyl-piperazine

4-(4-chloro-5-trifluoromethyl-pyrimidin-2-ylamino)-benzoyl Chloride

Downstream raw materials:

[4-(4-cyclopentylamino-5-trifluoromethyl-pyrimidin-2-ylamino)-phenyl]-(4-methyl-piperazin-1-yl)-methanone

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