(S)-4-isopropyl-3-(2-(((S)-1-(4-(piperazin-1-ylmethyl)phenyl)ethyl)amino)pyrimidin-4-yl)oxazolidin-2-one

Base Information

Chemical Name:(S)-4-isopropyl-3-(2-(((S)-1-(4-(piperazin-1-ylmethyl)phenyl)ethyl)amino)pyrimidin-4-yl)oxazolidin-2-one
CAS No.:1429176-51-1
Molecular Formula:C₂₃H₃₂N₆O₂
Molecular Weight:424.546
Hs Code.:

Synonyms:(S)-4-isopropyl-3-(2-(((S)-1-(4-(piperazin-1-ylmethyl)phenyl)ethyl)amino)pyrimidin-4-yl)oxazolidin-2-one

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Chemical Property of (S)-4-isopropyl-3-(2-(((S)-1-(4-(piperazin-1-ylmethyl)phenyl)ethyl)amino)pyrimidin-4-yl)oxazolidin-2-one

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Technology Process of (S)-4-isopropyl-3-(2-(((S)-1-(4-(piperazin-1-ylmethyl)phenyl)ethyl)amino)pyrimidin-4-yl)oxazolidin-2-one

There total 17 articles about (S)-4-isopropyl-3-(2-(((S)-1-(4-(piperazin-1-ylmethyl)phenyl)ethyl)amino)pyrimidin-4-yl)oxazolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: tert-butyl 4-(4-((S)-1-((4-((S)-4-isopropyl-2-oxooxazolidin-3-yl)pyrimidin-2-yl)amino)ethyl)benzyl)piperazine-1-carboxylate

: 1429176-51-1
(S)-4-isopropyl-3-(2-(((S)-1-(4-(piperazin-1-ylmethyl)phenyl)ethyl)amino)pyrimidin-4-yl)oxazolidin-2-one

Guidance literature:: With trifluoroacetic acid; In dichloromethane; for 4h;

Reference yield: 82.0%

: 1429176-78-2
benzyl 4-(4-((S)-1-((4-((S)-4-isopropyl-2-oxooxazolidin-3-yl)pyrimidin-2-yl)amino)ethyl)benzyl)piperazine-1-carboxylate

: 1429176-51-1
(S)-4-isopropyl-3-(2-(((S)-1-(4-(piperazin-1-ylmethyl)phenyl)ethyl)amino)pyrimidin-4-yl)oxazolidin-2-one

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In ethanol;

Reference yield:

: benzyl (1-(4-bromophenyl)-2-fluoroethyl)carbamate

: 1429176-51-1
(S)-4-isopropyl-3-(2-(((S)-1-(4-(piperazin-1-ylmethyl)phenyl)ethyl)amino)pyrimidin-4-yl)oxazolidin-2-one

Guidance literature:: Multi-step reaction with 9 steps

1: palladium diacetate; 1,1'-bis-(diphenylphosphino)ferrocene; triethylamine / acetonitrile / 24 h / 85 °C / 5171.62 Torr / Autoclave; Sealed tube

2: sodium hydroxide; water / tetrahydrofuran; methanol

3: dimethylsulfide borane complex / tetrahydrofuran / 2.5 h / 0 - 70 °C

4: palladium 10% on activated carbon; hydrogen / ethanol / 20 °C

5: thionyl chloride / dichloromethane / 4 h / 0 - 20 °C

6: potassium carbonate / acetonitrile / 24 h / 60 °C

7: sodium hydroxide; water / ethanol / 3.5 h / 20 °C

8: N-ethyl-N,N-diisopropylamine; cesium fluoride / dimethyl sulfoxide / 25 h / 60 - 90 °C

9: trifluoroacetic acid / dichloromethane / 4 h

With 1,1'-bis-(diphenylphosphino)ferrocene; thionyl chloride; dimethylsulfide borane complex; palladium 10% on activated carbon; water; hydrogen; palladium diacetate; potassium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; cesium fluoride; trifluoroacetic acid; sodium hydroxide; In tetrahydrofuran; methanol; ethanol; dichloromethane; dimethyl sulfoxide; acetonitrile;