(5'R)-N₆-benzoyl-5'-O-(4,4-dimethoxytrityl)-5',8-cyclo-2'-deoxyadenosine

Base Information

Chemical Name:(5'R)-N₆-benzoyl-5'-O-(4,4-dimethoxytrityl)-5',8-cyclo-2'-deoxyadenosine
CAS No.:222736-10-9
Molecular Formula:C₃₈H₃₃N₅O₆
Molecular Weight:655.71
Hs Code.:

(5'R)-N<sub>6</sub>-benzoyl-5'-O-(4,4-dimethoxytrityl)-5',8-cyclo-2'-deoxyadenosine

Synonyms:(5'R)-N₆-benzoyl-5'-O-(4,4-dimethoxytrityl)-5',8-cyclo-2'-deoxyadenosine

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Chemical Property of (5'R)-N₆-benzoyl-5'-O-(4,4-dimethoxytrityl)-5',8-cyclo-2'-deoxyadenosine

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Technology Process of (5'R)-N₆-benzoyl-5'-O-(4,4-dimethoxytrityl)-5',8-cyclo-2'-deoxyadenosine

There total 7 articles about (5'R)-N₆-benzoyl-5'-O-(4,4-dimethoxytrityl)-5',8-cyclo-2'-deoxyadenosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 222736-09-6
(5'R)-N₆-benzoyl-3'-O-(tert-butyldimethylsilyl)-5'-O-(4,4-dimethoxytrityl)-5',8-cyclo-2'-deoxyadenosine

: 222736-10-9
(5'R)-N₆-benzoyl-5'-O-(4,4-dimethoxytrityl)-5',8-cyclo-2'-deoxyadenosine

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; for 4h;
DOI:10.1080/07328319908044708

Reference yield:

: 211919-88-9
(5?'S)-N⁶-benzoyl-3?'-O-(tert-butyldimethylsilyl)-5?',8-cyclo-2?'-deoxyadenosine

: 222736-10-9
(5'R)-N₆-benzoyl-5'-O-(4,4-dimethoxytrityl)-5',8-cyclo-2'-deoxyadenosine

Guidance literature:: Multi-step reaction with 4 steps

1: 0.913 g / (C₂H₅)3N / pyridine; CH₂Cl₂ / 3 h / 20 °C

2: 0.4 g / KO₂; 18-C-6 crown ether / dimethylsulfoxide; 1,2-dimethoxy-ethane / 9 h / 20 °C

3: 0.136 g / pyridine / 4 h / 80 °C

4: 63 mg / tetrabutylammonium fluoride / tetrahydrofuran / 4 h / 20 °C

With 18-crown-6 ether; tetrabutyl ammonium fluoride; triethylamine; In tetrahydrofuran; pyridine; 1,2-dimethoxyethane; dichloromethane; dimethyl sulfoxide;
DOI:10.1021/tx9802668

Reference yield:

: 222736-08-5
(5?'R)-N⁶-benzoyl-3?'-O-(tert-butyldimethylsilyl)-5?',8-cyclo-2?'-deoxyadenosine

: 222736-10-9
(5'R)-N₆-benzoyl-5'-O-(4,4-dimethoxytrityl)-5',8-cyclo-2'-deoxyadenosine

Guidance literature:: Multi-step reaction with 2 steps

1: 0.136 g / pyridine / 4 h / 80 °C

2: 63 mg / tetrabutylammonium fluoride / tetrahydrofuran / 4 h / 20 °C

With tetrabutyl ammonium fluoride; In tetrahydrofuran; pyridine;
DOI:10.1021/tx9802668