methyl 2-(2-((triethylsilyl)ethynyl)-6-(trifluoromethyl)phenyl)acetate

Base Information

• Chemical Name: methyl 2-(2-((triethylsilyl)ethynyl)-6-(trifluoromethyl)phenyl)acetate
• CAS No.: 1566585-06-5
• Molecular Formula: C₁₈H₂₃F₃O₂Si
• Molecular Weight: 356.46
• Mol file: 1566585-06-5.mol

Synonyms:methyl 2-(2-((triethylsilyl)ethynyl)-6-(trifluoromethyl)phenyl)acetate

Chemical Property of methyl 2-(2-((triethylsilyl)ethynyl)-6-(trifluoromethyl)phenyl)acetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 2-(2-((triethylsilyl)ethynyl)-6-(trifluoromethyl)phenyl)acetate

There total 2 articles about methyl 2-(2-((triethylsilyl)ethynyl)-6-(trifluoromethyl)phenyl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

2-triethylsilylacetylene (1777-03-3) + methyl 2-(2-bromo-6-(trifluoromethyl)phenyl)acetate (1566585-04-3) → methyl 2-(2-((triethylsilyl)ethynyl)-6-(trifluoromethyl)phenyl)acetate (1566585-06-5)

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; N-ethyl-N,N-diisopropylamine; triphenylphosphine; In N,N-dimethyl-formamide; at 90 - 100 ℃; for 1.16667h; Microwave irradiation; Inert atmosphere;

Reference yield:

2-(2-bromo-6-(trifluoromethyl)phenyl)acetic acid (1159512-50-1) → methyl 2-(2-((triethylsilyl)ethynyl)-6-(trifluoromethyl)phenyl)acetate (1566585-06-5)

Guidance literature:

Multi-step reaction with 2 steps

1: diethyl ether; methanol; toluene / 20 h / 20 °C

2: copper(l) iodide; N-ethyl-N,N-diisopropylamine; triphenylphosphine; bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 1.17 h / 90 - 100 °C / Microwave irradiation; Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; N-ethyl-N,N-diisopropylamine; triphenylphosphine; In methanol; diethyl ether; N,N-dimethyl-formamide; toluene;

Reference yield: 95.0%

methyl 2-(2-((triethylsilyl)ethynyl)-6-(trifluoromethyl)phenyl)acetate (1566585-06-5) → methyl 2-(2-ethynyl-6-(trifluoromethyl)phenyl)acetate (1566585-07-6)

Guidance literature:

With potassium carbonate; In methanol; at 20 ℃; for 0.166667h;

upstream raw materials:

2-(2-bromo-6-(trifluoromethyl)phenyl)acetic acid

2-triethylsilylacetylene

methyl 2-(2-bromo-6-(trifluoromethyl)phenyl)acetate

Downstream raw materials:

methyl 2-(2-ethynyl-6-(trifluoromethyl)phenyl)acetate