4-[2-(5-chloro-2-fluoro-phenyl)-[1,8]naphthyridin-4-yl]-2-(2-morpholin-4-yl-ethyl)-2H-[2,7]naphthyridin-1-one

Base Information

Chemical Name:4-[2-(5-chloro-2-fluoro-phenyl)-[1,8]naphthyridin-4-yl]-2-(2-morpholin-4-yl-ethyl)-2H-[2,7]naphthyridin-1-one
CAS No.:1353968-39-4
Molecular Formula:C₂₈H₂₃ClFN₅O₂
Molecular Weight:515.974
Hs Code.:

Synonyms:4-[2-(5-chloro-2-fluoro-phenyl)-[1,8]naphthyridin-4-yl]-2-(2-morpholin-4-yl-ethyl)-2H-[2,7]naphthyridin-1-one

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Chemical Property of 4-[2-(5-chloro-2-fluoro-phenyl)-[1,8]naphthyridin-4-yl]-2-(2-morpholin-4-yl-ethyl)-2H-[2,7]naphthyridin-1-one

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Technology Process of 4-[2-(5-chloro-2-fluoro-phenyl)-[1,8]naphthyridin-4-yl]-2-(2-morpholin-4-yl-ethyl)-2H-[2,7]naphthyridin-1-one

There total 9 articles about 4-[2-(5-chloro-2-fluoro-phenyl)-[1,8]naphthyridin-4-yl]-2-(2-morpholin-4-yl-ethyl)-2H-[2,7]naphthyridin-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1323919-45-4
2-(5-chloro-2-fluoro-phenyl)-[1,8]naphthyridine-4-boronic acid

: 1353970-32-7
4-iodo-2-(2-morpholin-4-yl-ethyl)-2H-[2,7]naphthyridin-1-one

: 1353968-39-4
4-[2-(5-chloro-2-fluoro-phenyl)-[1,8]naphthyridin-4-yl]-2-(2-morpholin-4-yl-ethyl)-2H-[2,7]naphthyridin-1-one

Guidance literature:: With sodium hydrogencarbonate; bis-triphenylphosphine-palladium(II) chloride; In water; N,N-dimethyl-formamide; at 80 ℃; for 18h; Inert atmosphere;

Reference yield:

: 5345-47-1
2-aminopyridin-3-carboxylic acid

: 1353968-39-4
4-[2-(5-chloro-2-fluoro-phenyl)-[1,8]naphthyridin-4-yl]-2-(2-morpholin-4-yl-ethyl)-2H-[2,7]naphthyridin-1-one

Guidance literature:: Multi-step reaction with 7 steps

1.1: sulfuric acid / 60 h / 79 °C / Industry scale

1.2: pH 7 / Cooling with ice; Industry scale

2.1: sodium ethanolate / ethanol / 1 h / 20 °C / Industry scale

2.2: 65 h / 85 °C / Industry scale

3.1: hydrogenchloride / water / 17.5 h / 72 °C / Industry scale; Reflux

3.2: 16 h / 5 - 8 °C / pH 5 / Industry scale

4.1: trichlorophosphate / toluene / 4 h / 100 °C

4.2: 20 °C

5.1: sodium hydrogencarbonate / bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide; water / 16 h / 80 °C / Inert atmosphere

6.1: potassium acetate / bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran / 16 h / 80 °C / Inert atmosphere

7.1: sodium hydrogencarbonate / bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide; water / 18 h / 80 °C / Inert atmosphere

With hydrogenchloride; sulfuric acid; sodium ethanolate; potassium acetate; sodium hydrogencarbonate; trichlorophosphate; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide; toluene;

Reference yield:

: 622-40-2
2-(morpholin-4-yl)ethanol

: 1353968-39-4
4-[2-(5-chloro-2-fluoro-phenyl)-[1,8]naphthyridin-4-yl]-2-(2-morpholin-4-yl-ethyl)-2H-[2,7]naphthyridin-1-one

Guidance literature:: Multi-step reaction with 2 steps

1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 18 h / 20 °C / Cooling with ice

2: sodium hydrogencarbonate / bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide; water / 18 h / 80 °C / Inert atmosphere

With di-isopropyl azodicarboxylate; sodium hydrogencarbonate; triphenylphosphine; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; water; N,N-dimethyl-formamide;