4-((1R)-2-{[6-({4-[3-(cyclopentylsulfonyl)phenyl]butyl}oxy)-hexyl]amino}-1-hydroxyethyl)-2-(hydroxymethyl)phenol

Base Information

Chemical Name:4-((1R)-2-{[6-({4-[3-(cyclopentylsulfonyl)phenyl]butyl}oxy)-hexyl]amino}-1-hydroxyethyl)-2-(hydroxymethyl)phenol
CAS No.:686350-63-0
Molecular Formula:C₃₀H₄₅NO₆S
Molecular Weight:547.756
Hs Code.:

Synonyms:4-((1R)-2-{[6-({4-[3-(cyclopentylsulfonyl)phenyl]butyl}oxy)-hexyl]amino}-1-hydroxyethyl)-2-(hydroxymethyl)phenol

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Chemical Property of 4-((1R)-2-{[6-({4-[3-(cyclopentylsulfonyl)phenyl]butyl}oxy)-hexyl]amino}-1-hydroxyethyl)-2-(hydroxymethyl)phenol

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Technology Process of 4-((1R)-2-{[6-({4-[3-(cyclopentylsulfonyl)phenyl]butyl}oxy)-hexyl]amino}-1-hydroxyethyl)-2-(hydroxymethyl)phenol

There total 9 articles about 4-((1R)-2-{[6-({4-[3-(cyclopentylsulfonyl)phenyl]butyl}oxy)-hexyl]amino}-1-hydroxyethyl)-2-(hydroxymethyl)phenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: 686351-02-0
(1R)-2-{[6-({4-[3-(cyclopentylsulfonyl)phenyl]butyl}oxy)-hexyl]amino}-1-(2,2-dimethyl-4H-1,3-benzodioxin-6-yl)-ethanol

: 686350-63-0
4-((1R)-2-{[6-({4-[3-(cyclopentylsulfonyl)phenyl]butyl}oxy)-hexyl]amino}-1-hydroxyethyl)-2-(hydroxymethyl)phenol

Guidance literature:: With acetic acid; In water; at 65 ℃; for 2h;
DOI:10.1021/jm401532g

Reference yield:

: 4-{(1R)-2-[(6-{4-[3-(cyclopentylsulfonyl)phenyl]butoxy}hexyl)amino]-1-hydroxyethyl}-2-(hydroxymethyl)phenol acetate

: 686350-63-0
4-((1R)-2-{[6-({4-[3-(cyclopentylsulfonyl)phenyl]butyl}oxy)-hexyl]amino}-1-hydroxyethyl)-2-(hydroxymethyl)phenol

Guidance literature:: With ammonia; In methanol; dichloromethane;

Reference yield:

: 686351-01-9
(5R)-3-[6-({4-[3-(cyclopentylsulfonyl)phenyl]butyl}oxy)-hexyl]-5-(2,2-dimethyl-4H-1,3-benzodioxin-6-yl)-1,3-oxazolidin-2-one

: 686350-63-0
4-((1R)-2-{[6-({4-[3-(cyclopentylsulfonyl)phenyl]butyl}oxy)-hexyl]amino}-1-hydroxyethyl)-2-(hydroxymethyl)phenol

Guidance literature:: Multi-step reaction with 2 steps

1: potassium trimethylsilonate / tetrahydrofuran / 1 h / 65 °C

2: acetic acid / water / 2 h / 65 °C

With potassium trimethylsilonate; acetic acid; In tetrahydrofuran; water;
DOI:10.1021/jm401532g