N-(2-iodo-ethyl)-4-methyl-N-(2,2,4-trimethyl-[1,3]dioxan-5-yl)-benzenesulfonamide

Base Information

Chemical Name:N-(2-iodo-ethyl)-4-methyl-N-(2,2,4-trimethyl-[1,3]dioxan-5-yl)-benzenesulfonamide
CAS No.:459457-05-7
Molecular Formula:C₁₆H₂₄INO₄S
Molecular Weight:453.341
Hs Code.:

<i>N</i>-(2-iodo-ethyl)-4-methyl-<i>N</i>-(2,2,4-trimethyl-[1,3]dioxan-5-yl)-benzenesulfonamide

Synonyms:N-(2-iodo-ethyl)-4-methyl-N-(2,2,4-trimethyl-[1,3]dioxan-5-yl)-benzenesulfonamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-(2-iodo-ethyl)-4-methyl-N-(2,2,4-trimethyl-[1,3]dioxan-5-yl)-benzenesulfonamide

Chemical Property:

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Technology Process of N-(2-iodo-ethyl)-4-methyl-N-(2,2,4-trimethyl-[1,3]dioxan-5-yl)-benzenesulfonamide

There total 7 articles about N-(2-iodo-ethyl)-4-methyl-N-(2,2,4-trimethyl-[1,3]dioxan-5-yl)-benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 459457-04-6
N-(2-hydroxy-ethyl)-4-methyl-N-(2,2,4-trimethyl-[1,3]dioxan-5-yl)-benzenesulfonamide

: 459457-05-7
N-(2-iodo-ethyl)-4-methyl-N-(2,2,4-trimethyl-[1,3]dioxan-5-yl)-benzenesulfonamide

Guidance literature:: With 1H-imidazole; iodine; triphenylphosphine; In toluene;
DOI:10.1016/S0040-4039(02)00833-X

Reference yield:

: 34235-88-6
(2S,3S)-3-hydroxy-2-(4-methylphenylsulfonamido)butanoic acid

: 459457-05-7
N-(2-iodo-ethyl)-4-methyl-N-(2,2,4-trimethyl-[1,3]dioxan-5-yl)-benzenesulfonamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: KHCO₃ / dimethylformamide

2.1: LiBH₄ / tetrahydrofuran

3.1: TsOH / CH₂Cl₂

4.1: 96 percent / NaH / dimethylformamide

5.1: OsO₄; NMO / acetone; H₂O

5.2: NaIO₄ / tetrahydrofuran; various solvent(s)

5.3: 100 percent / NaBH₄ / methanol

6.1: 97 percent / I₂; Ph₃P; imidazole / toluene

With 1H-imidazole; osmium(VIII) oxide; lithium borohydride; N-methyl-2-indolinone; iodine; sodium hydride; potassium hydrogencarbonate; toluene-4-sulfonic acid; triphenylphosphine; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; acetone; toluene;
DOI:10.1016/S0040-4039(02)00833-X

Reference yield:

: 43188-53-0
(2S,3R)-methyl-N-(4-methylphenylsulfonyl)-3-hydroxy-2-aminobutanoate

: 459457-05-7
N-(2-iodo-ethyl)-4-methyl-N-(2,2,4-trimethyl-[1,3]dioxan-5-yl)-benzenesulfonamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: LiBH₄ / tetrahydrofuran

2.1: TsOH / CH₂Cl₂

3.1: 96 percent / NaH / dimethylformamide

4.1: OsO₄; NMO / acetone; H₂O

4.2: NaIO₄ / tetrahydrofuran; various solvent(s)

4.3: 100 percent / NaBH₄ / methanol

5.1: 97 percent / I₂; Ph₃P; imidazole / toluene

With 1H-imidazole; osmium(VIII) oxide; lithium borohydride; N-methyl-2-indolinone; iodine; sodium hydride; toluene-4-sulfonic acid; triphenylphosphine; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; acetone; toluene;
DOI:10.1016/S0040-4039(02)00833-X