(S)-N-Naphthalen-1-yl-4-(4-thiocarbamoyl-phenyl)-2-(toluene-4-sulfonylamino)-butyramide

Base Information

Chemical Name:(S)-N-Naphthalen-1-yl-4-(4-thiocarbamoyl-phenyl)-2-(toluene-4-sulfonylamino)-butyramide
CAS No.:82098-90-6
Molecular Formula:C₂₈H₂₇N₃O₃S₂
Molecular Weight:517.673
Hs Code.:

Synonyms:(S)-N-Naphthalen-1-yl-4-(4-thiocarbamoyl-phenyl)-2-(toluene-4-sulfonylamino)-butyramide

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Chemical Property of (S)-N-Naphthalen-1-yl-4-(4-thiocarbamoyl-phenyl)-2-(toluene-4-sulfonylamino)-butyramide

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Technology Process of (S)-N-Naphthalen-1-yl-4-(4-thiocarbamoyl-phenyl)-2-(toluene-4-sulfonylamino)-butyramide

There total 7 articles about (S)-N-Naphthalen-1-yl-4-(4-thiocarbamoyl-phenyl)-2-(toluene-4-sulfonylamino)-butyramide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.5%

: 82098-69-9
4-(4-Cyano-phenyl)-N-naphthalen-1-yl-2-(toluene-4-sulfonylamino)-butyramide

: 82098-90-6
(S)-N-Naphthalen-1-yl-4-(4-thiocarbamoyl-phenyl)-2-(toluene-4-sulfonylamino)-butyramide

Guidance literature:: With TEA; hydrogen sulfide; In pyridine; Ambient temperature;

Reference yield:

: 100-27-6
2-(4-nitrophenyl)ethanol

: 82098-90-6
(S)-N-Naphthalen-1-yl-4-(4-thiocarbamoyl-phenyl)-2-(toluene-4-sulfonylamino)-butyramide

Guidance literature:: Multi-step reaction with 7 steps

1: 70 percent / H₂ / Raney-nickel / methanol / Ambient temperature

2: 1.) NaNO₂/conc. HCl; 2.) CuCN/NaCN / 1.) H₂O, 0-5 deg C; 2.) benzene, 0-5 deg C, 30 min; room temp., 4 h

3: 63 percent / PBr₃ / CHCl₃ / 1.5 h / Heating

4: 1.) KI; 2.) Na / 1.) EtOH, reflux; 2.) EtOH, reflux, 5 h

6: 40 percent / benzene / Ambient temperature

7: 70.5 percent / H₂S (gas), TEA / pyridine / Ambient temperature

With hydrogenchloride; TEA; hydrogen sulfide; sodium cyanide; hydrogen; sodium; phosphorus tribromide; potassium iodide; sodium nitrite; nickel; In pyridine; methanol; chloroform; benzene;

Reference yield:

: 72054-56-9
4-(2-bromoethyl)benzonitrile

: 82098-90-6
(S)-N-Naphthalen-1-yl-4-(4-thiocarbamoyl-phenyl)-2-(toluene-4-sulfonylamino)-butyramide

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) KI; 2.) Na / 1.) EtOH, reflux; 2.) EtOH, reflux, 5 h

3: 40 percent / benzene / Ambient temperature

4: 70.5 percent / H₂S (gas), TEA / pyridine / Ambient temperature

With TEA; hydrogen sulfide; sodium; potassium iodide; In pyridine; benzene;