1-<3-propyl>-4-piperidinone

Base Information

• Chemical Name: 1-<3-propyl>-4-piperidinone
• CAS No.: 80119-57-9
• Molecular Formula: C₂₀H₂₂F₂N₂O
• Molecular Weight: 344.404

Synonyms:1-<3-propyl>-4-piperidinone

Chemical Property of 1-<3-propyl>-4-piperidinone

Chemical Property:

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Technology Process of 1-<3-propyl>-4-piperidinone

There total 2 articles about 1-<3-propyl>-4-piperidinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

4-piperidone hydrochloride (41979-39-9) + N-(3-chloropropyl)-4-fluoro-N-(4-fluorophenyl)benzenamine (80119-31-9) → 1-<3-propyl>-4-piperidinone (80119-57-9)

Guidance literature:

With sodium carbonate; sodium iodide; In N,N-dimethyl-formamide; at 75 - 90 ℃; for 20h;

DOI:10.1021/jm00150a011

Reference yield:

4,4-ethylenedioxy-piperidine (177-11-7) + N-(3-bromopropyl)-4-fluoro-N-(4-fluorophenyl)benzenamine (80129-10-8) → 1-<3-propyl>-4-piperidinone (80119-57-9)

Guidance literature:

With sodium carbonate; In hydrogenchloride; ethanol; n-heptane; ethyl acetate;

Reference yield:

1-<3-propyl>-4-piperidinone (80119-57-9) + 1-Bromo-4-fluorobenzene (460-00-4) → 4-(4-fluorophenyl)-1-(3-[bis(4-fluorophenyl)amino]propyl)-4-piperidinol hydrochloride

Guidance literature:

With hydrogenchloride; iodine; magnesium; In isopropyl alcohol;

upstream raw materials:

4-piperidone hydrochloride

N-(3-chloropropyl)-4-fluoro-N-(4-fluorophenyl)benzenamine

4,4-ethylenedioxy-piperidine

N-(3-bromopropyl)-4-fluoro-N-(4-fluorophenyl)benzenamine

Downstream raw materials:

1-<3-propyl>-4-<(4-chlorophenyl)amino>-4-piperidinecarbonitrile

1-<3-propyl>-4-<(4-chlorophenyl)amino>-4-piperidinecarboxamide

8-<3-propyl>-1-(4-chlorophenyl)-1,3,8-triazaspiro<4.5>decan-4-one

8-<3-propyl>-1-(4-chlorophenyl)-1,3,8-triazaspiro<4.5>dec-2-en-4-one

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