1,4-dimethyl-6-<(1H-indol-3-yl)methyl>-3-<(3-phenylmethoxy)phenylmethylene>-(Z)-2,5-piperazinedione

Base Information

• Chemical Name: 1,4-dimethyl-6-<(1H-indol-3-yl)methyl>-3-<(3-phenylmethoxy)phenylmethylene>-(Z)-2,5-piperazinedione
• CAS No.: 180857-76-5
• Molecular Formula: C₂₉H₂₇N₃O₃
• Molecular Weight: 465.552
• Mol file: 180857-76-5.mol

Synonyms:1,4-dimethyl-6-<(1H-indol-3-yl)methyl>-3-<(3-phenylmethoxy)phenylmethylene>-(Z)-2,5-piperazinedione

Chemical Property of 1,4-dimethyl-6-<(1H-indol-3-yl)methyl>-3-<(3-phenylmethoxy)phenylmethylene>-(Z)-2,5-piperazinedione

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1,4-dimethyl-6-<(1H-indol-3-yl)methyl>-3-<(3-phenylmethoxy)phenylmethylene>-(Z)-2,5-piperazinedione

There total 2 articles about 1,4-dimethyl-6-<(1H-indol-3-yl)methyl>-3-<(3-phenylmethoxy)phenylmethylene>-(Z)-2,5-piperazinedione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1,4-dimethyl-3-<(3-phenylmethoxy)phenylmethylene>-(Z)-2,5-piperazinedione (149862-46-4) + Methanesulfonate(1H-indol-3-ylmethyl)-trimethyl-ammonium; → 1,4-dimethyl-6-<(1H-indol-3-yl)methyl>-3-<(3-phenylmethoxy)phenylmethylene>-(Z)-2,5-piperazinedione (180857-76-5)

Guidance literature:

With dilithium tetrachlorocuprate; lithium diisopropyl amide; Yield given. Multistep reaction; 1.) THF, hexane, -78 deg C, 2.) THF, hexane, -78 deg C, 40 min;

DOI:10.1016/0040-4020(96)00408-5

Reference yield:

1-(1H-indol-3-yl)-N,N,N-trimethylmethanaminium methyl sulfate (19260-03-8) + 1,4-dimethyl-3-<(3-phenylmethoxy)phenylmethylene>-(Z)-2,5-piperazinedione (149862-46-4) → 1,4-dimethyl-6-<(1H-indol-3-yl)methyl>-3-<(3-phenylmethoxy)phenylmethylene>-(Z)-2,5-piperazinedione (180857-76-5)

Guidance literature:

With lithium diisopropyl amide; dilithium tetrachlorocuprate; Yield given. Multistep reaction; 1) THF, -78 deg C, 2) -78 deg C to 23 deg C;

DOI:10.1021/jo00065a001

Reference yield: 80.0%

1,4-dimethyl-6-<(1H-indol-3-yl)methyl>-3-<(3-phenylmethoxy)phenylmethylene>-(Z)-2,5-piperazinedione (180857-76-5) → C29H27N3O3

Guidance literature:

hydrogen bromide; In 1,4-dioxane; for 3h; Heating;

DOI:10.1021/jo00065a001

upstream raw materials:

1-(1H-indol-3-yl)-N,N,N-trimethylmethanaminium methyl sulfate

1,4-dimethyl-3-<(3-phenylmethoxy)phenylmethylene>-(Z)-2,5-piperazinedione

Downstream raw materials:

1,4-dimethyl-6-<<(1-phenylmethoxycarbonyl)indol-3-yl>methyl>-3-<(3-phenylmethoxy)phenylmethylene>-(Z)-2,5-piperazinedione