Technology Process of 2,2-Dimethyl-propionic acid 2-benzyl-4-fluoro-pent-4-enyl ester
There total 6 articles about 2,2-Dimethyl-propionic acid 2-benzyl-4-fluoro-pent-4-enyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 95 percent / acetyl chloride / 12 h
2: 95 percent / LiAlH4 / tetrahydrofuran / 3 h / 0 °C
3: 88 percent / pyridine / CH2Cl2 / 14 h / 0 - 20 °C
4: 1.) N-bromosuccinimide, pyridinium poly(hydrogen fluoride), 2.) potassium tert-butoxide / 1.) ether, 0-20 deg C, 2 h, 2.) THF, -30 - -20 deg C, 2 h
With
pyridine; N-Bromosuccinimide; lithium aluminium tetrahydride; potassium tert-butylate; pyridine hydrogenfluoride; acetyl chloride;
In
tetrahydrofuran; dichloromethane;
DOI:10.1016/S0968-0896(97)10038-4
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 95 percent / LiAlH4 / tetrahydrofuran / 3 h / 0 °C
2: 88 percent / pyridine / CH2Cl2 / 14 h / 0 - 20 °C
3: 1.) N-bromosuccinimide, pyridinium poly(hydrogen fluoride), 2.) potassium tert-butoxide / 1.) ether, 0-20 deg C, 2 h, 2.) THF, -30 - -20 deg C, 2 h
With
pyridine; N-Bromosuccinimide; lithium aluminium tetrahydride; potassium tert-butylate; pyridine hydrogenfluoride;
In
tetrahydrofuran; dichloromethane;
DOI:10.1016/S0968-0896(97)10038-4
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 88 percent / pyridine / CH2Cl2 / 14 h / 0 - 20 °C
2: 1.) N-bromosuccinimide, pyridinium poly(hydrogen fluoride), 2.) potassium tert-butoxide / 1.) ether, 0-20 deg C, 2 h, 2.) THF, -30 - -20 deg C, 2 h
With
pyridine; N-Bromosuccinimide; potassium tert-butylate; pyridine hydrogenfluoride;
In
dichloromethane;
DOI:10.1016/S0968-0896(97)10038-4
