(7-bromo-6-nitro-4-quinazolinyl)-(3-chloro-4-fluorophenyl)amine hydrochloride

Base Information

Chemical Name:(7-bromo-6-nitro-4-quinazolinyl)-(3-chloro-4-fluorophenyl)amine hydrochloride
CAS No.:451494-36-3
Molecular Formula:C₁₄H₇BrClFN₄O₂*ClH
Molecular Weight:434.052
Hs Code.:

Synonyms:(7-bromo-6-nitro-4-quinazolinyl)-(3-chloro-4-fluorophenyl)amine hydrochloride

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Chemical Property of (7-bromo-6-nitro-4-quinazolinyl)-(3-chloro-4-fluorophenyl)amine hydrochloride

Chemical Property:

Purity/Quality:

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Technology Process of (7-bromo-6-nitro-4-quinazolinyl)-(3-chloro-4-fluorophenyl)amine hydrochloride

There total 1 articles about (7-bromo-6-nitro-4-quinazolinyl)-(3-chloro-4-fluorophenyl)amine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 451494-35-2
7-bromo-8-nitro-4-quinazolinone

: 451494-34-1
7-bromo-6-nitroquinazolin-4(3H)-one

: 367-21-5
3-chloro-4-fluorophenylamine

: 451494-36-3
(7-bromo-6-nitro-4-quinazolinyl)-(3-chloro-4-fluorophenyl)amine hydrochloride

Guidance literature:: 7-bromo-8-nitro-4-quinazolinone; 7-bromo-6-nitroquinazolin-4(3H)-one; With thionyl chloride; N,N-dimethyl-formamide; for 2h; Heating / reflux;

3-chloro-4-fluorophenylamine; In dichloromethane; isopropyl alcohol; at 20 ℃; for 4h;

Reference yield: 50.0%

: 169194-80-3
1-methyl-4-(2-methylbut-3-yn-2-yl)piperazine

: 451494-36-3
(7-bromo-6-nitro-4-quinazolinyl)-(3-chloro-4-fluorophenyl)amine hydrochloride

: 451494-31-8
(3-chloro-4-fluorophenyl)-{7-[3-methyl-3-(4-methyl-1-piperazinyl)-1-butynyl]-6-nitro-4-quinazolinyl}amine

Guidance literature:: With triethylamine; palladium diacetate; copper(l) iodide; triphenylphosphine; In dimethyl sulfoxide; at 80 ℃; for 9h;

Reference yield:

: 451494-36-3
(7-bromo-6-nitro-4-quinazolinyl)-(3-chloro-4-fluorophenyl)amine hydrochloride

: 451494-80-7
C₁₂H₂₂N₂

: 451493-23-5
C₂₆H₂₈ClFN₆O₂

Guidance literature:: (7-bromo-6-nitro-4-quinazolinyl)-(3-chloro-4-fluorophenyl)amine hydrochloride; With triethylamine; In methanol; water;

C₁₂H₂₂N₂; With triethylamine; palladium diacetate; triphenylphosphine; In DMF (N,N-dimethyl-formamide); at 80 ℃; for 3h;