N-(1-(2-chlorophenyl)pent-1-yn-3-yl)-N'-(3,4-dihydronaphthalen-1(2H)-ylidene)-4-methylbenzenesulfonohydrazide

Base Information

• Chemical Name: N-(1-(2-chlorophenyl)pent-1-yn-3-yl)-N'-(3,4-dihydronaphthalen-1(2H)-ylidene)-4-methylbenzenesulfonohydrazide
• CAS No.: 1314111-13-1
• Molecular Formula: C₂₈H₂₇ClN₂O₂S
• Molecular Weight: 491.054
• Mol file: 1314111-13-1.mol

Synonyms:N-(1-(2-chlorophenyl)pent-1-yn-3-yl)-N'-(3,4-dihydronaphthalen-1(2H)-ylidene)-4-methylbenzenesulfonohydrazide

Chemical Property of N-(1-(2-chlorophenyl)pent-1-yn-3-yl)-N'-(3,4-dihydronaphthalen-1(2H)-ylidene)-4-methylbenzenesulfonohydrazide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(1-(2-chlorophenyl)pent-1-yn-3-yl)-N'-(3,4-dihydronaphthalen-1(2H)-ylidene)-4-methylbenzenesulfonohydrazide

There total 6 articles about N-(1-(2-chlorophenyl)pent-1-yn-3-yl)-N'-(3,4-dihydronaphthalen-1(2H)-ylidene)-4-methylbenzenesulfonohydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

1-(2-chlorophenyl)pent-1-yn-3-yl methyl carbonate (1314111-01-7) + 1-tetralone tosylhydrazone (17336-59-3) → N-(1-(2-chlorophenyl)pent-1-yn-3-yl)-N'-(3,4-dihydronaphthalen-1(2H)-ylidene)-4-methylbenzenesulfonohydrazide (1314111-13-1)

Guidance literature:

With dichloro bis(acetonitrile) palladium(II); 1,3-bis-(diphenylphosphino)propane; caesium carbonate; In 1,4-dioxane; at 80 ℃; for 4h; Inert atmosphere;

DOI:10.1002/chem.201100248

Reference yield:

pent-1-yn-3-ol (4187-86-4) → N-(1-(2-chlorophenyl)pent-1-yn-3-yl)-N'-(3,4-dihydronaphthalen-1(2H)-ylidene)-4-methylbenzenesulfonohydrazide (1314111-13-1)

Guidance literature:

Multi-step reaction with 3 steps

1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / dimethyl sulfoxide / 40 - 45 °C

2: pyridine; dmap / dichloromethane / 2 h / 0 - 20 °C

3: dichloro bis(acetonitrile) palladium(II); 1,3-bis-(diphenylphosphino)propane; caesium carbonate / 1,4-dioxane / 4 h / 80 °C / Inert atmosphere

With pyridine; dmap; bis-triphenylphosphine-palladium(II) chloride; dichloro bis(acetonitrile) palladium(II); copper(l) iodide; 1,3-bis-(diphenylphosphino)propane; caesium carbonate; triethylamine; In 1,4-dioxane; dichloromethane; dimethyl sulfoxide;

DOI:10.1002/chem.201100248

Reference yield:

C11H11ClO (1314111-34-6) → N-(1-(2-chlorophenyl)pent-1-yn-3-yl)-N'-(3,4-dihydronaphthalen-1(2H)-ylidene)-4-methylbenzenesulfonohydrazide (1314111-13-1)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine; dmap / dichloromethane / 2 h / 0 - 20 °C

2: dichloro bis(acetonitrile) palladium(II); 1,3-bis-(diphenylphosphino)propane; caesium carbonate / 1,4-dioxane / 4 h / 80 °C / Inert atmosphere

With pyridine; dmap; dichloro bis(acetonitrile) palladium(II); 1,3-bis-(diphenylphosphino)propane; caesium carbonate; In 1,4-dioxane; dichloromethane;

DOI:10.1002/chem.201100248

upstream raw materials:

pent-1-yn-3-ol

1-(2-chlorophenyl)pent-1-yn-3-yl methyl carbonate

1-tetralone tosylhydrazone

C₁₁H₁₁ClO