(S)-2-(2,6-dimethylphenyl)-6-(5-isopropyl-2-methylphenyl)-4-(4-methoxy-3,3-dimethylpiperidin-1-yl)-5,6,7,8-tetrahydro-1,6-naphthyridine

Base Information

Chemical Name:(S)-2-(2,6-dimethylphenyl)-6-(5-isopropyl-2-methylphenyl)-4-(4-methoxy-3,3-dimethylpiperidin-1-yl)-5,6,7,8-tetrahydro-1,6-naphthyridine
CAS No.:1421251-71-9
Molecular Formula:C₃₄H₄₅N₃O
Molecular Weight:511.751
Hs Code.:

Synonyms:(S)-2-(2,6-dimethylphenyl)-6-(5-isopropyl-2-methylphenyl)-4-(4-methoxy-3,3-dimethylpiperidin-1-yl)-5,6,7,8-tetrahydro-1,6-naphthyridine

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Chemical Property of (S)-2-(2,6-dimethylphenyl)-6-(5-isopropyl-2-methylphenyl)-4-(4-methoxy-3,3-dimethylpiperidin-1-yl)-5,6,7,8-tetrahydro-1,6-naphthyridine

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Technology Process of (S)-2-(2,6-dimethylphenyl)-6-(5-isopropyl-2-methylphenyl)-4-(4-methoxy-3,3-dimethylpiperidin-1-yl)-5,6,7,8-tetrahydro-1,6-naphthyridine

There total 8 articles about (S)-2-(2,6-dimethylphenyl)-6-(5-isopropyl-2-methylphenyl)-4-(4-methoxy-3,3-dimethylpiperidin-1-yl)-5,6,7,8-tetrahydro-1,6-naphthyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1421251-66-2
(S)-2-(2,6-dimethylphenyl)-6-(5-isopropyl-2-methylphenyl)-4-(4-methoxy-3,3-dimethylpiperidin-1-yl)-7,8-dihydro-1,6-naphthyridin-5(6H)-one

: 1421251-71-9
(S)-2-(2,6-dimethylphenyl)-6-(5-isopropyl-2-methylphenyl)-4-(4-methoxy-3,3-dimethylpiperidin-1-yl)-5,6,7,8-tetrahydro-1,6-naphthyridine

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; at 55 ℃; for 1.5h;

Reference yield:

: 1218994-35-4
methyl 2,4,6-trichloronicotinate

: 1421251-71-9
(S)-2-(2,6-dimethylphenyl)-6-(5-isopropyl-2-methylphenyl)-4-(4-methoxy-3,3-dimethylpiperidin-1-yl)-5,6,7,8-tetrahydro-1,6-naphthyridine

Guidance literature:: Multi-step reaction with 7 steps

1.1: methanol / 17 h / 20 °C

2.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / water; N,N-dimethyl-formamide / 16.5 h / 110 °C / Inert atmosphere

2.2: 4.5 h / 110 °C

3.1: acetic acid / toluene / 12 h / 110 °C

4.1: potassium trimethylsilonate / 1,4-dioxane / 3 h / 140 °C / Sealed tube

5.1: Vilsmeier's reagent / dichloromethane / 2.83 h / 20 °C

6.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl acetamide / 4 h / 110 °C

7.1: lithium aluminium tetrahydride / tetrahydrofuran / 1.5 h / 55 °C

With methanol; lithium aluminium tetrahydride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium trimethylsilonate; sodium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; 1,4-dioxane; dichloromethane; N,N-dimethyl acetamide; water; N,N-dimethyl-formamide; toluene;

Reference yield:

: 17228-75-0
2,6-dichloro-4-methoxy pyridine

: 1421251-71-9
(S)-2-(2,6-dimethylphenyl)-6-(5-isopropyl-2-methylphenyl)-4-(4-methoxy-3,3-dimethylpiperidin-1-yl)-5,6,7,8-tetrahydro-1,6-naphthyridine

Guidance literature:: Multi-step reaction with 7 steps

1.1: 2,2,6,6-tetramethylpiperidinylmagnesium chloride lithium chloride complex / toluene; tetrahydrofuran / 0.33 h / 20 °C

1.2: 0.25 h

2.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / water; N,N-dimethyl-formamide / 16.5 h / 110 °C / Inert atmosphere

2.2: 4.5 h / 110 °C

3.1: acetic acid / toluene / 12 h / 110 °C

4.1: potassium trimethylsilonate / 1,4-dioxane / 3 h / 140 °C / Sealed tube

5.1: Vilsmeier's reagent / dichloromethane / 2.83 h / 20 °C

6.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl acetamide / 4 h / 110 °C

7.1: lithium aluminium tetrahydride / tetrahydrofuran / 1.5 h / 55 °C

With lithium aluminium tetrahydride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 2,2,6,6-tetramethylpiperidinylmagnesium chloride lithium chloride complex; potassium trimethylsilonate; sodium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; 1,4-dioxane; dichloromethane; N,N-dimethyl acetamide; water; N,N-dimethyl-formamide; toluene;